Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2023 Mar 16

PMID 36922933

Authors

Jason A White

Ernest T Kaninjing

Kayode A Adeniji

Paul Jibrin

John O Obafunwa

Chidiebere N Ogo

Faruk Mohammed

Ademola Popoola

Omolara A Fatiregun

Olabode P Oluwole

Balasubramanyam Karanam

Isra Elhussin

Stefan Ambs

Wei Tang

Melissa Davis

Paz Polak

Moray J Campbell

Kathryn R Brignole

Solomon O Rotimi

Windy Dean-Colomb

Folake T Odedina

Damali N Martin

Clayton Yates

Affiliations

Soon will be listed here.

Abstract

Significance: MAA have higher rates of prostate cancer incidence and mortality, however, are severely underrepresented in genomic studies. This is the first study utilizing whole-exome sequencing in NG men to identify West African ancestry-linked variant patterns that impact DNA damage repair pathways.

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