Interactomics in Plant Defence: Progress and Opportunities

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2023 Mar 15

PMID 36920596

Authors

Nur Hikmah Mostaffa

Ahmad Husaini Suhaimi

Aisyafaznim Al-Idrus

Affiliations

Soon will be listed here.

Abstract

Interactomics is a branch of systems biology that deals with the study of protein-protein interactions and how these interactions influence phenotypes. Identifying the interactomes involved during host-pathogen interaction events may bring us a step closer to deciphering the molecular mechanisms underlying plant defence. Here, we conducted a systematic review of plant interactomics studies over the last two decades and found that while a substantial progress has been made in the field, plant-pathogen interactomics remains a less-travelled route. As an effort to facilitate the progress in this field, we provide here a comprehensive research pipeline for an in planta plant-pathogen interactomics study that encompasses the in silico prediction step to the validation step, unconfined to model plants. We also highlight four challenges in plant-pathogen interactomics with plausible solution(s) for each.

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