Randomized, Double-blind, Four-arm Pilot Study on the Effects of Chicken Essence and Type II Collagen Hydrolysate on Joint, Bone, and Muscle Functions

Overview

Journal Nutr J

Publisher Biomed Central

Specialty Nutritional Sciences

Date 2023 Mar 15

PMID 36918892

Authors

Chun-Chieh Chen

Shih-Sheng Chang

Chih-Hsiang Chang

Chih-Chien Hu

Yoshihiro Nakao

Shan May Yong

Yen Ling Ow Mandy

Chia Juan Lim

Eric Kian-Shiun Shim

Hsin-Nung Shih

Affiliations

Soon will be listed here.

Abstract

Background: Knee osteoarthritis (OA) is a leading cause of disability among older adults. Medical and surgical treatments are costly and associated with side effects. A natural nutraceutical, collagen hydrolysate, has received considerable attention due to its relieving effects on OA-associated symptoms. This study investigated the effects of hydrolyzed collagen type II (HC-II) and essence of chicken (BRAND'S Essence of Chicken) with added HC-II (EC-HC-II) on joint, muscle, and bone functions among older adults with OA.

Methods: Patients (n = 160) with grade 1-3 knee OA according to the Kellgren-Lawrence classification system, joint pain for ≥ 3 months, and a Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score of > 6 were randomly assigned with equal probability to consume EC-HC-II, HC-II, glucosamine HCl, or a placebo for 24 weeks in combination with resistance training. Outcome measurements were WOMAC score, visual analogue scale (VAS) pain score, grip strength, fat-free mass (FFM), and bone mass.

Results: All groups exhibited similar levels of improvement in WOMAC index scores after 24 weeks. HC-II significantly reduced VAS pain score by 0.9 ± 1.89 (p = 0.034) after 14 days. A repeated-measures analysis of variance showed that HC-II reduced pain levels more than the placebo did (mean ± standard error: - 1.3 ± 0.45, p = 0.021) after 14 days; the EC-HC-II group also had significantly higher FFM than the glucosamine HCl (p = 0.02) and placebo (p = 0.017) groups and significantly higher grip strength than the glucosamine HCl group (p = 0.002) at 24 weeks.

Conclusion: HC-II reduces pain, and EC-HC-II may improve FFM and muscle strength. This suggests that EC-HC-II may be a novel holistic solution for mobility by improving joint, muscle, and bone health among older adults. Large-scale studies should be conducted to validate these findings.

Trial Registration: This trial was retrospectively registered at ClinicalTrials.gov (NCT04483024).

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