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A Novel Insight into the Immune-Related Interaction of Inflammatory Cytokines in Benign Prostatic Hyperplasia

Overview
Journal J Clin Med
Specialty General Medicine
Date 2023 Mar 11
PMID 36902608
Authors
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Abstract

Benign prostatic hyperplasia (BPH) is a common male condition that impacts many men's quality of life by generating lower urinary tract symptoms (LUTS). In recent years, inflammation has become very common in the prostate, and BPH with inflammation has a higher International Prostate Symptom Score (IPSS) score and an enlarged prostate. Chronic inflammation leads to tissue damage and the release of pro-inflammatory cytokines, which play an important role in the pathogenesis of BPH. We will focus on current advancements in pro-inflammatory cytokines in BPH, as well as the future of pro-inflammatory cytokine research.

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References
1.
Bostwick D, de la Roza G, Dundore P, Corica F, Iczkowski K . Intraepithelial and stromal lymphocytes in the normal human prostate. Prostate. 2003; 55(3):187-93. DOI: 10.1002/pros.10224. View

2.
Li J, Li Y, Cao D, Huang Y, Peng L, Meng C . The association between histological prostatitis and benign prostatic hyperplasia: a single-center retrospective study. Aging Male. 2022; 25(1):88-93. DOI: 10.1080/13685538.2022.2050360. View

3.
Buck A . Is there a scientific basis for the therapeutic effects of serenoa repens in benign prostatic hyperplasia? Mechanisms of action. J Urol. 2004; 172(5 Pt 1):1792-9. DOI: 10.1097/01.ju.0000140503.11467.8e. View

4.
Tsai Y, Tong Y, Cheng J, Lee C, Yang F, Lee H . Pumpkin seed oil and phytosterol-F can block testosterone/prazosin-induced prostate growth in rats. Urol Int. 2006; 77(3):269-74. DOI: 10.1159/000094821. View

5.
Pappu R, Ramirez-Carrozzi V, Sambandam A . The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunology. 2011; 134(1):8-16. PMC: 3173690. DOI: 10.1111/j.1365-2567.2011.03465.x. View