» Articles » PMID: 36899268

SPECT/CT, PET/CT and PET/MRI: Oncologic and Infectious Applications and Protocol Considerations

Overview
Journal Pediatr Radiol
Specialty Pediatrics
Date 2023 Mar 10
PMID 36899268
Authors
Affiliations
Soon will be listed here.
Abstract

Functional imaging is playing an increasingly important role in pediatric radiology. Hybrid imaging techniques utilizing PET/CT (positron emission tomography/computed tomography), PET/MRI (positron emission tomography/magnetic resonance imaging), or SPECT/CT (single photon emission computed tomography/computed tomography) are now available in nearly every clinical practice. There are an increasing number of indications for the use of functional imaging, including oncologic and infectious indications, and it is essential to select and design the hybrid imaging protocol in order to optimize both the functional and anatomic components of the examination. Optimizing the protocol includes strategies for dose reduction, judicious use of contrast media and diagnostic quality imaging as appropriate, and for the greatest reduction in exposure to ionizing radiation, utilizing PET/MRI, whenever available. This review will provide an overview of hybrid imaging protocol considerations with a focus on oncologic and infectious indications.

Citing Articles

Development of Novel Tc-Labeled Hydrazinoicotinamide-Modified Ubiquicidin 29-41 Complexes with Improved Target-to-Nontarget Ratios for Bacterial Infection Imaging.

Jiang Y, Wang Q, Yin G, Feng J, Ruan Q, Han P ACS Pharmacol Transl Sci. 2025; 8(2):470-483.

PMID: 39974636 PMC: 11833726. DOI: 10.1021/acsptsci.4c00599.


Noninvasive in vivo imaging of macrophages: understanding tumor microenvironments and delivery of therapeutics.

Gangadaran P, Onkar A, Rajendran R, Goenka A, Oh J, Khan F Biomark Res. 2025; 13(1):20.

PMID: 39865337 PMC: 11770947. DOI: 10.1186/s40364-025-00735-9.


AI-based automatic patient positioning in a digital-BGO PET/CT scanner: efficacy and impact.

Kennedy J, Palchan-Hazan T, Keidar Z EJNMMI Phys. 2025; 12(1):4.

PMID: 39831942 PMC: 11746997. DOI: 10.1186/s40658-025-00715-w.


Radiopharmaceuticals and their applications in medicine.

Zhang S, Wang X, Gao X, Chen X, Li L, Li G Signal Transduct Target Ther. 2025; 10(1):1.

PMID: 39747850 PMC: 11697352. DOI: 10.1038/s41392-024-02041-6.


X-ray fluoroscopy guided localization and steering of miniature robots using virtual reality enhancement.

Alabay H, Le T, Ceylan H Front Robot AI. 2024; 11:1495445.

PMID: 39605865 PMC: 11599259. DOI: 10.3389/frobt.2024.1495445.


References
1.
Fahey F . Dosimetry of Pediatric PET/CT. J Nucl Med. 2009; 50(9):1483-91. DOI: 10.2967/jnumed.108.054130. View

2.
Wagenknecht G, Kaiser H, Mottaghy F, Herzog H . MRI for attenuation correction in PET: methods and challenges. MAGMA. 2012; 26(1):99-113. PMC: 3572388. DOI: 10.1007/s10334-012-0353-4. View

3.
Fahey F, Goodkind A, MacDougall R, Oberg L, Ziniel S, Cappock R . Operational and Dosimetric Aspects of Pediatric PET/CT. J Nucl Med. 2017; 58(9):1360-1366. PMC: 6944174. DOI: 10.2967/jnumed.116.182899. View

4.
Parisi M, Bermo M, Alessio A, Sharp S, Gelfand M, Shulkin B . Optimization of Pediatric PET/CT. Semin Nucl Med. 2017; 47(3):258-274. DOI: 10.1053/j.semnuclmed.2017.01.002. View

5.
Colleran G, Kwatra N, Oberg L, Grant F, Drubach L, Callahan M . How we read pediatric PET/CT: indications and strategies for image acquisition, interpretation and reporting. Cancer Imaging. 2017; 17(1):28. PMC: 5678769. DOI: 10.1186/s40644-017-0130-8. View