Functional Capacity Testing in Patients with Pulmonary Hypertension (PH) Using the One-minute Sit-to-stand Test (1-min STST)

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2023 Mar 9

PMID 36893125

Authors

Christina Kronberger

Roya Anahita Mousavi

Begum Ozturk

Robin Willixhofer

Theresa-Marie Dachs

Rene Rettl

Luciana Camuz-Ligios

Nima Rassoulpour

Christoph Krall

Brigitte Litschauer

Roza Badr Eslam

Affiliations

Soon will be listed here.

Abstract

Background: The one-minute sit-to-stand-test (1-min STST) is a quick, space saving test to evaluate functional capacity. Exercise testing plays an important role in the long-term follow-up of pulmonary hypertension (PH) patients and is currently evaluated using the six-minute-walk-test (6MWT). The aim of the study was to assess the convergent validity of the 1-min STST in patients with PH and its association with markers of PH severity.

Methods: We evaluated 106 PH patients with the 1-min-STST and 6MWT and measured cardiorespiratory parameters (heart rate, blood pressure, oxygen saturation) before and after test conduction. N-terminal pro brain-type natriuretic peptide (NT-proBNP), WHO functional class (WHO-FC) and mean pulmonary artery pressure (mPAP) were defined as markers of PH severity.

Results: Strong correlation was found between performances of 1-min STST and 6MWT (r = .711, p < .001), indicating convergent validity. Both tests were inversely associated with NT-proBNP (STST: r = -.405, p < .001; 6MWT: r = -.358, p < .001), WHO-FC (STST: r = -.591, p < .001; 6MWT: r = -.643, p < .001) and mPAP (STST: r = -.280, p < .001; 6MWT: r = -.250, p < .001). Significant changes in cardiorespiratory parameters were observed in both tests (all p < 0.001). Further the post-exercise cardiorespiratory parameters correlated strongly between the 1-min STST and 6MWT (all r ≥ .651, all p < .001).

Conclusion: The 1-min STST demonstrated good convergent validity with the 6MWT and was associated with markers of PH severity. Furthermore, both exercise tests caused similar cardiorespiratory responses.

Citing Articles

Correction: Functional capacity testing in patients with pulmonary hypertension (PH) using the one-minute sit-to-stand test (1-min STST).

Kronberger C, Mousavi R, Ozturk B, Willixhofer R, Dachs T, Rettl R PLoS One. 2025; 20(1):e0317857.

PMID: 39820237 PMC: 11737663. DOI: 10.1371/journal.pone.0317857.

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Zamboti C, Pimpao H, Bertin L, Krinski G, Garcia T, Dos Santos Filho S J Clin Med. 2024; 13(22).

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Kronberger C, Willixhofer R, Mousavi R, Grzeda M, Litschauer B, Krall C PLoS One. 2024; 19(5):e0301483.

PMID: 38809846 PMC: 11135673. DOI: 10.1371/journal.pone.0301483.

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