It's a Small World for Parasites: Evidence Supporting the North American Invasion of European

Overview

Journal Proc Biol Sci

Specialty Biology

Date 2023 Mar 8

PMID 36883278

Authors

Maria A Santa

Gerald Umhang

Claudia Klein

Danielle M Grant

Kathreen E Ruckstuhl

Marco Musiani

John S Gilleard

Alessandro Massolo

Affiliations

Soon will be listed here.

Abstract

(), the causative agent of human alveolar echinococcosis (AE), is present in the Holarctic region, and several genetic variants deem to have differential infectivity and pathogenicity. An unprecedented outbreak of human AE cases in Western Canada infected with a European-like strain circulating in wild hosts warranted assessment of whether this strain was derived from a recent invasion or was endemic but undetected. Using nuclear and mitochondrial markers, we investigated the genetic diversity of in wild coyotes and red foxes from Western Canada, compared the genetic variants identified to global isolates and assessed their spatial distribution to infer possible invasion dynamics. Genetic variants from Western Canada were closely related to the original European clade, with lesser genetic diversity than that expected for a long-established strain and spatial genetic discontinuities within the study area, supporting the hypothesis of a relatively recent invasion with various founder events.

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