Accurate Post-Calibration Predictions for Noninvasive Glucose Measurements in People Using Confocal Raman Spectroscopy

Overview

Journal ACS Sens

Publisher American Chemical Society

Specialty Biotechnology

Date 2023 Mar 6

PMID 36877178

Authors

Anders Pors

Kaspar G Rasmussen

Rune Inglev

Nina Jendrike

Amalie Philipps

Ajenthen G Ranjan

Vibe Vestergaard

Jan E Henriksen

Kirsten Norgaard

Guido Freckmann

Karl D Hepp

Michael C Gerstenberg

Anders Weber

Affiliations

Soon will be listed here.

Abstract

In diabetes prevention and care, invasiveness of glucose measurement impedes efficient therapy and hampers the identification of people at risk. Lack of calibration stability in non-invasive technology has confined the field to short-term proof of principle. Addressing this challenge, we demonstrate the first practical use of a Raman-based and portable non-invasive glucose monitoring device used for at least 15 days following calibration. In a home-based clinical study involving 160 subjects with diabetes, the largest of its kind to our knowledge, we find that the measurement accuracy is insensitive to age, sex, and skin color. A subset of subjects with type 2 diabetes highlights promising real-life results with 99.8% of measurements within A + B zones in the consensus error grid and a mean absolute relative difference of 14.3%. By overcoming the problem of calibration stability, we remove the lingering uncertainty about the practical use of non-invasive glucose monitoring, boding a new, non-invasive era in diabetes monitoring.

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