Effects of Oleic Acid And/or Exercise on Diet-induced Thermogenesis and Obesity in Rats: Involvement of Beige Adipocyte Differentiation and Macrophage M1 Inhibition

Overview

Journal Res Pharm Sci

Specialty Chemistry

Date 2023 Mar 6

PMID 36873275

Authors

Abeer Salama

Mohamed M Amin

Azza Hassan

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Obesity is a public health problem and the existence of beige adipocytes has got interested as a potential therapeutic involvement for obesity and obesity-associated diseases. Adipose tissue M1 macrophage inhibition, also, has a vital role in obesity down-regulating adipose tissue inflammation and the use of natural compounds such as oleic acid with exercise has been proposed. The present study aimed to evaluate the possible effects of oleic acid and exercise on diet-induced thermogenesis and obesity in rats.

Experimental Approach: Wister albino rats were categorized into six groups. Group I: normal control, group II: oleic acid group (9.8 mg/kg; orally), group III: high-fat diet (HFD), group IV: HFD plus oleic acid, group V: HFD plus exercise training, group VI: HFD plus exercise training and oleic acid.

Findings/results: Oleic acid administration and/or exercise significantly decreased body weight, TG, and cholesterol, as well as elevated HDL levels. Furthermore, oleic acid administration and/or exercise reduced serum MDA, TNF-α, and IL-6 levels, elevated the levels of GSH and irisin, increased the expression of UCP1, CD137, and CD206, and reduced CD11c expression.

Conclusion And Implications: Oleic acid supplementation and/or exercise could be used as therapeutic agents for treating obesity its antioxidant and anti-inflammatory activities, stimulation of beige adipocyte differentiation, and macrophage M1 inhibition.

Citing Articles

Extract Suppresses Adiposity by Inhibiting Adipogenesis and Promoting Adipocyte Browning via AMPK Activation in 3T3-L1 Cells.

Dayarathne L, Jasmadi , Ko S, Yim M, Lee J, Kim J J Microbiol Biotechnol. 2024; 34(8):1688-1697.

PMID: 39086228 PMC: 11380521. DOI: 10.4014/jmb.2404.04041.

STAT4 Mediates IL-6 Trans-Signaling Arrhythmias in High Fat Diet Guinea Pig Heart.

Corbin A, Aromolaran K, Aromolaran A Int J Mol Sci. 2024; 25(14).

PMID: 39063055 PMC: 11277091. DOI: 10.3390/ijms25147813.

7-MEGA™ inhibits adipogenesis in 3T3-L1 adipocytes and suppresses obesity in high-fat-diet-induced obese C57BL/6 mice.

Won Y, Bak S, Chandimali N, Park E, Lim H, Kwon H Lipids Health Dis. 2024; 23(1):192.

PMID: 38909257 PMC: 11193219. DOI: 10.1186/s12944-024-02175-0.

Amelioration of obesity induction by a high-fat diet and related inflammation by Phasa fish (Setipinna phasa) oil in BALB/c mice.

Panchali T, Dutta A, Das P, Khatun A, Kar R, Mondal S J Appl Biomed. 2024; 22(1):49-58.

PMID: 38505970 DOI: 10.32725/jab.2024.003.

Possible Mechanisms Linking Obesity, Steroidogenesis, and Skeletal Muscle Dysfunction.

Sheptulina A, Antyukh K, Kiselev A, Mitkovskaya N, Drapkina O Life (Basel). 2023; 13(6).

PMID: 37374197 PMC: 10302755. DOI: 10.3390/life13061415.

References

Salama A, Mostafa R, Elgohary R . Effect of L-carnitine on potassium dichromate-induced nephrotoxicity in rats: modulation of PI3K/AKT signaling pathway. Res Pharm Sci. 2022; 17(2):153-163. PMC: 8860102. DOI: 10.4103/1735-5362.335174. View

Goncalves-de-Albuquerque C, Medeiros-de-Moraes I, de Jesus Oliveira F, Burth P, Bozza P, Castro Faria M . Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis. PLoS One. 2016; 11(4):e0153607. PMC: 4831806. DOI: 10.1371/journal.pone.0153607. View

El-Baz F, Salama A, Salama R . Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin. Biomed Res Int. 2020; 2020:1295492. PMC: 6970482. DOI: 10.1155/2020/1295492. View

Sidossis L, Kajimura S . Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. J Clin Invest. 2015; 125(2):478-86. PMC: 4319444. DOI: 10.1172/JCI78362. View

Jung S, Kim K . Exercise-induced PGC-1α transcriptional factors in skeletal muscle. Integr Med Res. 2017; 3(4):155-160. PMC: 5481761. DOI: 10.1016/j.imr.2014.09.004. View

Kern P, Saghizadeh M, Ong J, Bosch R, Deem R, Simsolo R . The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest. 1995; 95(5):2111-9. PMC: 295809. DOI: 10.1172/JCI117899. View

Tutunchi H, Ostadrahimi A, Saghafi-Asl M . The Effects of Diets Enriched in Monounsaturated Oleic Acid on the Management and Prevention of Obesity: a Systematic Review of Human Intervention Studies. Adv Nutr. 2020; 11(4):864-877. PMC: 7360458. DOI: 10.1093/advances/nmaa013. View

Tietze F . Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem. 1969; 27(3):502-22. DOI: 10.1016/0003-2697(69)90064-5. View

Fossati P, PRENCIPE L . Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982; 28(10):2077-80. View

10.

Wentworth J, Naselli G, Brown W, Doyle L, Phipson B, Smyth G . Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes. 2010; 59(7):1648-56. PMC: 2889764. DOI: 10.2337/db09-0287. View

11.

Keller P, Vollaard N, Gustafsson T, Gallagher I, Sundberg C, Rankinen T . A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J Appl Physiol (1985). 2010; 110(1):46-59. PMC: 3253010. DOI: 10.1152/japplphysiol.00634.2010. View

12.

Wu P, Zhang F, Dai Y, Han L, Chen S . Serum TNF-α, GTH and MDA of high-fat diet-induced obesity and obesity resistant rats. Saudi Pharm J. 2016; 24(3):333-6. PMC: 4881199. DOI: 10.1016/j.jsps.2016.04.011. View

13.

Su R, Yan J, Yang H . Transgenerational Glucose Intolerance of Tumor Necrosis Factor with Epigenetic Alteration in Rat Perirenal Adipose Tissue Induced by Intrauterine Hyperglycemia. J Diabetes Res. 2016; 2016:4952801. PMC: 4735892. DOI: 10.1155/2016/4952801. View

14.

Bostrom P, Wu J, Jedrychowski M, Korde A, Ye L, Lo J . A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012; 481(7382):463-8. PMC: 3522098. DOI: 10.1038/nature10777. View

15.

Sramek J, Nemcova-Furstova V, Polak J, Kovar J . Hypoxia Modulates Effects of Fatty Acids on NES2Y Human Pancreatic β-cells. Int J Mol Sci. 2019; 20(14). PMC: 6678120. DOI: 10.3390/ijms20143441. View

16.

Huang I, Lee J, Ketheeswaran P, Jones C, Revicki D, Wu A . Does personality affect health-related quality of life? A systematic review. PLoS One. 2017; 12(3):e0173806. PMC: 5371329. DOI: 10.1371/journal.pone.0173806. View

17.

Salama A, Fayed H, Elgohary R . L-carnitine alleviated acute lung injuries induced by potassium dichromate in rats: involvement of Nrf2/HO-1 signaling pathway. Heliyon. 2021; 7(6):e07207. PMC: 8207205. DOI: 10.1016/j.heliyon.2021.e07207. View

18.

Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E . Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005; 46(11):2347-55. DOI: 10.1194/jlr.M500294-JLR200. View

19.

Zhang J, Wu H, Ma S, Jing F, Yu C, Gao L . Transcription regulators and hormones involved in the development of brown fat and white fat browning: transcriptional and hormonal control of brown/beige fat development. Physiol Res. 2018; 67(3):347-362. DOI: 10.33549/physiolres.933650. View

20.

Richmond W . Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem. 1973; 19(12):1350-6. View