Modulation of Neuronal Excitability by Binge Alcohol Drinking

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2023 Mar 3

PMID 36866357

Authors

Pablo Gimenez-Gomez

Timmy Le

Gilles E Martin

Affiliations

Soon will be listed here.

Abstract

Drug use poses a serious threat to health systems throughout the world. The number of consumers rises every year being alcohol the drug of abuse most consumed causing 3 million deaths (5.3% of all deaths) worldwide and 132.6 million disability-adjusted life years. In this review, we present an up-to-date summary about what is known regarding the global impact of binge alcohol drinking on brains and how it affects the development of cognitive functions, as well as the various preclinical models used to probe its effects on the neurobiology of the brain. This will be followed by a detailed report on the state of our current knowledge of the molecular and cellular mechanisms underlying the effects of binge drinking on neuronal excitability and synaptic plasticity, with an emphasis on brain regions of the meso-cortico limbic neurocircuitry.

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