Effect of Gastric Distension with Concurrent Small Intestinal Saline or Glucose Infusion on Incretin Hormone Secretion in Healthy Individuals: A Randomized, Controlled, Crossover Study

Overview

Journal Diabetes Obes Metab

Specialty Endocrinology

Date 2023 Mar 3

PMID 36864654

Authors

Ryan J Jalleh

Laurence G Trahair

Tongzhi Wu

Scott Standfield

Christine Feinle-Bisset

Christopher K Rayner

Michael Horowitz

Karen L Jones

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the effect of gastric distension, induced using a gastric 'barostat', on the secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in the presence and absence of small intestinal nutrients in healthy individuals.

Materials And Methods: Eight healthy participants (two females, six males, mean age 69.3 ± 1.2 years, body mass index 23.5 ± 0.8 kg/m ) were each studied on four occasions when they received an intraduodenal infusion of either (i) 0.9% saline or (ii) glucose delivered at a rate of 3 kcal/min both with, and without, an intragastric balloon with the pressure set to 8 mmHg above the intragastric minimum distending pressure.

Results: Following intraduodenal saline or glucose infusion, there was no difference in plasma GLP-1 with or without gastric distension (P = 1.00 for both saline and glucose infusions). There was also no difference in plasma GIP with or without gastric distension (P = 1.00 for saline infusion and P = .99 for glucose infusion).

Conclusions: Gastric distension, either alone or during small intestinal glucose exposure, does not stimulate incretin hormone secretion significantly in healthy humans.

Citing Articles

Effect of gastric distension with concurrent small intestinal saline or glucose infusion on incretin hormone secretion in healthy individuals: A randomized, controlled, crossover study.

Jalleh R, Trahair L, Wu T, Standfield S, Feinle-Bisset C, Rayner C Diabetes Obes Metab. 2023; 25(7):1849-1854.

PMID: 36864654 PMC: 10947269. DOI: 10.1111/dom.15042.

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