Epigenetics As a Versatile Regulator of Fibrosis

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2023 Mar 2

PMID 36864460

Authors

Yangdan Liu

Dongsheng Wen

Chiakang Ho

Li Yu

Danning Zheng

Steven OReilly

Ya Gao

Qingfeng Li

Yifan Zhang

Affiliations

Soon will be listed here.

Abstract

Fibrosis, a process caused by excessive deposition of extracellular matrix (ECM), is a common cause and outcome of organ failure and even death. Researchers have made many efforts to understand the mechanism of fibrogenesis and to develop therapeutic strategies; yet, the outcome remains unsatisfactory. In recent years, advances in epigenetics, including chromatin remodeling, histone modification, DNA methylation, and noncoding RNA (ncRNA), have provided more insights into the fibrotic process and have suggested the possibility of novel therapy for organ fibrosis. In this review, we summarize the current research on the epigenetic mechanisms involved in organ fibrosis and their possible clinical applications.

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