Study of Correlation Between Structure and Shape-Memory Effect/Drug-Release Profile of Polyurethane/Hydroxyapatite Composites for Antibacterial Implants

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2023 Feb 28

PMID 36850222

Authors

Monika Bil

Magdalena Jurczyk-Kowalska

Kamil Kopec

Marcin Heljak

Affiliations

Soon will be listed here.

Abstract

The effectiveness of multifunctional composites that combine a shape-memory polyurethane (PU) matrix with hydroxyapatite (HA) as a bioactive agent and antibiotics molecules results from a specific composite structure. In this study, structure-function correlations of PU-based composites consisting of 3, 5, and 10 (wt%) of HA and (5 wt%) of gentamicin sulfate (GeS) as a model drug were investigated. The performed analysis revealed that increasing HA content up to 5 wt% enhanced hydrogen-bonding interaction within the soft segments of the PU. Differential-scanning-calorimetry (DSC) analysis confirmed the semi-crystalline structure of the composites. Hydroxyapatite enhanced thermal stability was confirmed by thermogravimetric analysis (TGA), and the water contact angle evaluated hydrophilicity. The shape-recovery coefficient (R) measured in water, decreased from 94% for the PU to 86% for the PU/GeS sample and to 88-91% for the PU/HA/GeS composites. These values were positively correlated with hydrogen-bond interactions evaluated using the Fourier-transform-infrared (FTIR) spectroscopy. Additionally, it was found that the shape-recovery process initiates drug release. After shape recovery, the drug concentration in water was 17 μg/mL for the PU/GeS sample and 33-47 μg/mL for the PU HA GeS composites. Antibacterial properties of developed composites were confirmed by the agar-diffusion test against Escherichia coli and Staphylococcus epidermidis.

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References

Mi H, Palumbo S, Jing X, Turng L, Li W, Peng X . Thermoplastic polyurethane/hydroxyapatite electrospun scaffolds for bone tissue engineering: effects of polymer properties and particle size. J Biomed Mater Res B Appl Biomater. 2014; 102(7):1434-44. DOI: 10.1002/jbm.b.33122. View

Ma C, Wei Q, Cao B, Cheng X, Tian J, Pu H . A multifunctional bioactive material that stimulates osteogenesis and promotes the vascularization bone marrow stem cells and their resistance to bacterial infection. PLoS One. 2017; 12(3):e0172499. PMC: 5373515. DOI: 10.1371/journal.pone.0172499. View

Du K, Gan Z . Shape memory behaviour of HA-g-PDLLA nanocomposites prepared via in situ polymerization. J Mater Chem B. 2020; 2(21):3340-3348. DOI: 10.1039/c3tb21861a. View

Caplin J, Garcia A . Implantable antimicrobial biomaterials for local drug delivery in bone infection models. Acta Biomater. 2019; 93:2-11. PMC: 6615972. DOI: 10.1016/j.actbio.2019.01.015. View

Liu W, Zhao Y, Wang R, Li J, Li J, Luo F . Post-Crosslinked Polyurethanes with Excellent Shape Memory Property. Macromol Rapid Commun. 2017; 38(23). DOI: 10.1002/marc.201700450. View

Purcar V, Raditoiu V, Nichita C, Balan A, Raditoiu A, Caprarescu S . Preparation and Characterization of Silica Nanoparticles and of Silica-Gentamicin Nanostructured Solution Obtained by Microwave-Assisted Synthesis. Materials (Basel). 2021; 14(8). PMC: 8074919. DOI: 10.3390/ma14082086. View

Ribeiro M, Monteiro F, Ferraz M . Infection of orthopedic implants with emphasis on bacterial adhesion process and techniques used in studying bacterial-material interactions. Biomatter. 2013; 2(4):176-94. PMC: 3568104. DOI: 10.4161/biom.22905. View

Zaleski S, Clark K, Smith M, Eilert J, Doty M, Van Duyne R . Identification and Quantification of Intravenous Therapy Drugs Using Normal Raman Spectroscopy and Electrochemical Surface-Enhanced Raman Spectroscopy. Anal Chem. 2017; 89(4):2497-2504. DOI: 10.1021/acs.analchem.6b04636. View

Turnbull G, Clarke J, Picard F, Riches P, Jia L, Han F . 3D bioactive composite scaffolds for bone tissue engineering. Bioact Mater. 2018; 3(3):278-314. PMC: 5935790. DOI: 10.1016/j.bioactmat.2017.10.001. View

10.

Senatov F, Niaza K, Zadorozhnyy M, Maksimkin A, Kaloshkin S, Estrin Y . Mechanical properties and shape memory effect of 3D-printed PLA-based porous scaffolds. J Mech Behav Biomed Mater. 2015; 57:139-48. DOI: 10.1016/j.jmbbm.2015.11.036. View

11.

Wischke C, Behl M, Lendlein A . Drug-releasing shape-memory polymers - the role of morphology, processing effects, and matrix degradation. Expert Opin Drug Deliv. 2013; 10(9):1193-205. DOI: 10.1517/17425247.2013.797406. View

12.

Jackson B, Bow A, Kannarpady G, Biris A, Anderson D, Dhar M . Polyurethane/nano-hydroxyapatite composite films as osteogenic platforms. J Biomater Sci Polym Ed. 2018; 29(12):1426-1443. DOI: 10.1080/09205063.2018.1464264. View

13.

Nie D, Yin X, Cai Z, Wang J . Effect of Crystallization on Shape Memory Effect of Poly(lactic Acid). Polymers (Basel). 2022; 14(8). PMC: 9028359. DOI: 10.3390/polym14081569. View

14.

Wischke C, Neffe A, Steuer S, Lendlein A . Evaluation of a degradable shape-memory polymer network as matrix for controlled drug release. J Control Release. 2009; 138(3):243-50. DOI: 10.1016/j.jconrel.2009.05.027. View

15.

Li L, Yu M, Li Y, Li Q, Yang H, Zheng M . Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration. Bioact Mater. 2020; 6(5):1255-1266. PMC: 7653289. DOI: 10.1016/j.bioactmat.2020.10.018. View

16.

Water J, Bohr A, Boetker J, Aho J, Sandler N, Nielsen H . Three-dimensional printing of drug-eluting implants: preparation of an antimicrobial polylactide feedstock material. J Pharm Sci. 2015; 104(3):1099-107. DOI: 10.1002/jps.24305. View

17.

Wang L, Yang X, Chen H, Gong T, Li W, Yang G . Design of triple-shape memory polyurethane with photo-cross-linking of cinnamon groups. ACS Appl Mater Interfaces. 2013; 5(21):10520-8. DOI: 10.1021/am402091m. View

18.

Staszczak M, Nabavian Kalat M, Golasinski K, Urbanski L, Takeda K, Matsui R . Characterization of Polyurethane Shape Memory Polymer and Determination of Shape Fixity and Shape Recovery in Subsequent Thermomechanical Cycles. Polymers (Basel). 2022; 14(21). PMC: 9658389. DOI: 10.3390/polym14214775. View

19.

Zhao W, Liu L, Zhang F, Leng J, Liu Y . Shape memory polymers and their composites in biomedical applications. Mater Sci Eng C Mater Biol Appl. 2019; 97:864-883. DOI: 10.1016/j.msec.2018.12.054. View

20.

Xia Y, He Y, Zhang F, Liu Y, Leng J . A Review of Shape Memory Polymers and Composites: Mechanisms, Materials, and Applications. Adv Mater. 2020; 33(6):e2000713. DOI: 10.1002/adma.202000713. View