Deconstructive Functionalization of Unstrained Cycloalkanols Via Electrochemically Generated Aromatic Radical Cations

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2023 Feb 27

PMID 36847269

Authors

James Harnedy

Hussain A Maashi

Albara A M A El Gehani

Matthew Burns

Louis C Morrill

Affiliations

Soon will be listed here.

Abstract

Herein we report an electrochemical approach for the deconstructive functionalization of cycloalkanols, where various alcohols, carboxylic acids, and -heterocycles are employed as nucleophiles. The method has been demonstrated across a broad range of cycloalkanol substrates, including various ring sizes and substituents, to access useful remotely functionalized ketone products (36 examples). The method was demonstrated on a gram scale via single-pass continuous flow, which exhibited increased productivity in relation to the batch process.

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