Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 Feb 25

PMID 36839911

Authors

Adina Cata

Ioana Maria Carmen Ienascu

Mariana Nela Stefanut

Dan Rosu

Oana-Raluca Pop

Affiliations

Soon will be listed here.

Abstract

Amphiphilic Janus dendrimers are arrangements containing both hydrophilic and hydrophobic units, capable of forming ordered aggregates by intermolecular noncovalent interactions between the dendrimer units. Compared to conventional dendrimers, these molecular self-assemblies possess particular and effective attributes i.e., the presence of different terminal groups, essential to design new elaborated materials. The present review will focus on the pharmaceutical and biomedical application of amphiphilic Janus dendrimers. Important information for the development of novel optimized pharmaceutical formulations, such as structural classification, synthetic pathways, properties and applications, will offer the complete characterization of this type of Janus dendrimers. This work will constitute an up-to-date background for dendrimer specialists involved in designing amphiphilic Janus dendrimer-based nanomaterials for future innovations in this promising field.

Citing Articles

Janus and Amphiphilic MoS 2D Sheets for Surface-Directed Orientational Assemblies toward Ex Vivo Dual Substrate Release.

Wang J, Li S, Yang L, Kwan C, Xie C, Cheung K Small Methods. 2024; 8(12):e2400533.

PMID: 38874104 PMC: 11671850. DOI: 10.1002/smtd.202400533.

Metallo-Glycodendrimeric Materials against Enterotoxigenic .

El Riz A, Tchoumi Neree A, Mousavifar L, Roy R, Chorfi Y, Mateescu M Microorganisms. 2024; 12(5).

PMID: 38792795 PMC: 11124148. DOI: 10.3390/microorganisms12050966.

Phosphorus-carrying cascade molecules: inner architecture to biomedical applications.

Thirumalai A, Elboughdiri N, Harini K, Girigoswami K, Girigoswami A Turk J Chem. 2024; 47(4):667-688.

PMID: 38174062 PMC: 10760543. DOI: 10.55730/1300-0527.3570.

Dendrimers: Exploring Their Wide Structural Variety and Applications.

Perez-Ferreiro M, M Abelairas A, Criado A, Gomez I, Mosquera J Polymers (Basel). 2023; 15(22).

PMID: 38006093 PMC: 10674315. DOI: 10.3390/polym15224369.

Janus Dendrimers as Nanocarriers of Ibuprofen, Chlorambucil and their Anticancer Activity.

Pedro-Hernandez L, Barajas-Mendoza I, Castillo-Rodriguez I, Klimova E, Ramirez-Apan T, Martinez-Garcia M Pharm Nanotechnol. 2023; 12(3):276-287.

PMID: 37592778 DOI: 10.2174/2211738511666230817160636.

References

Shi P, Qu Y, Liu C, Khan H, Sun P, Zhang W . Redox-Responsive Multicompartment Vesicles of Ferrocene-Containing Triblock Terpolymer Exhibiting On-Off Switchable Pores. ACS Macro Lett. 2022; 5(1):88-93. DOI: 10.1021/acsmacrolett.5b00928. View

Du X, Wang Z, Wang Y . Redox-sensitive dendrimersomes assembled from amphiphilic Janus dendrimers for siRNA delivery. Biomater Sci. 2018; 6(8):2122-2129. DOI: 10.1039/c8bm00491a. View

Zhang S, Sun H, Hughes A, Draghici B, Lejnieks J, Leowanawat P . "Single-single" amphiphilic janus dendrimers self-assemble into uniform dendrimersomes with predictable size. ACS Nano. 2014; 8(2):1554-65. DOI: 10.1021/nn405790x. View

Sikwal D, Kalhapure R, Govender T . An emerging class of amphiphilic dendrimers for pharmaceutical and biomedical applications: Janus amphiphilic dendrimers. Eur J Pharm Sci. 2016; 97:113-134. DOI: 10.1016/j.ejps.2016.11.013. View

Filippi M, Patrucco D, Martinelli J, Botta M, Castro-Hartmann P, Tei L . Novel stable dendrimersome formulation for safe bioimaging applications. Nanoscale. 2015; 7(30):12943-54. DOI: 10.1039/c5nr02695d. View

Plunkett S, Khatib M, Sencan I, Porter J, Kumar A, Collins J . In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing. Nanoscale. 2020; 12(4):2657-2672. PMC: 7101076. DOI: 10.1039/c9nr07778b. View

Sanchez A, Villalonga A, Martinez-Garcia G, Parrado C, Villalonga R . Dendrimers as Soft Nanomaterials for Electrochemical Immunosensors. Nanomaterials (Basel). 2019; 9(12). PMC: 6955849. DOI: 10.3390/nano9121745. View

Lancelot A, Gonzalez-Pastor R, Claveria-Gimeno R, Romero P, Abian O, Martin-Duque P . Cationic poly(ester amide) dendrimers: alluring materials for biomedical applications. J Mater Chem B. 2020; 6(23):3956-3968. DOI: 10.1039/c8tb00639c. View

Filippi M, Remotti D, Botta M, Terreno E, Tei L . GdDOTAGA(C18)2: an efficient amphiphilic Gd(iii) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes. Chem Commun (Camb). 2015; 51(98):17455-8. DOI: 10.1039/c5cc06032j. View

10.

Gusdon A, Faraday N, Aita J, Kumar S, Mehta I, Choi H . Dendrimer nanotherapy for severe COVID-19 attenuates inflammation and neurological injury markers and improves outcomes in a phase2a clinical trial. Sci Transl Med. 2022; 14(654):eabo2652. DOI: 10.1126/scitranslmed.abo2652. View

11.

Gu H, Ciganda R, Castel P, Vax A, Gregurec D, Irigoyen J . Redox-Robust Pentamethylferrocene Polymers and Supramolecular Polymers, and Controlled Self-Assembly of Pentamethylferricenium Polymer-Embedded Ag, AgI, and Au Nanoparticles. Chemistry. 2015; 21(50):18177-86. DOI: 10.1002/chem.201503248. View

12.

Su C, Liu Y, Li R, Wu W, Fawcett J, Gu J . Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems. Adv Drug Deliv Rev. 2019; 143:97-114. DOI: 10.1016/j.addr.2019.06.008. View

13.

Tang R, Zhou S, Cheng Z, Yu G, Peng Q, Zeng H . Janus second-order nonlinear optical dendrimers: their controllable molecular topology and corresponding largely enhanced performance. Chem Sci. 2017; 8(1):340-347. PMC: 5365064. DOI: 10.1039/c6sc02956f. View

14.

Buzzacchera I, Xiao Q, Han H, Rahimi K, Li S, Kostina N . Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes. Biomacromolecules. 2018; 20(2):712-727. PMC: 6571140. DOI: 10.1021/acs.biomac.8b01405. View

15.

Liu Y, Yu C, Jin H, Jiang B, Zhu X, Zhou Y . A supramolecular Janus hyperbranched polymer and its photoresponsive self-assembly of vesicles with narrow size distribution. J Am Chem Soc. 2013; 135(12):4765-70. DOI: 10.1021/ja3122608. View

16.

Ghann W, Kang H, Uddin J, Gonawala S, Mahatabuddin S, Ali M . Dendrimer-based Nanoparticle for Dye Sensitized Solar Cells with Improved Efficiency. J Nanomed Nanotechnol. 2018; 9(2). PMC: 5976458. DOI: 10.4172/2157-7439.1000496. View

17.

Falanga A, Del Genio V, Kaufman E, Zannella C, Franci G, Weck M . Engineering of Janus-Like Dendrimers with Peptides Derived from Glycoproteins of Herpes Simplex Virus Type 1: Toward a Versatile and Novel Antiviral Platform. Int J Mol Sci. 2021; 22(12). PMC: 8234430. DOI: 10.3390/ijms22126488. View

18.

Sui X, Shui L, Cui J, Xie Y, Song J, van den Berg A . Redox-responsive organometallic microgel particles prepared from poly(ferrocenylsilane)s generated using microfluidics. Chem Commun (Camb). 2014; 50(23):3058-60. DOI: 10.1039/c3cc49501a. View

19.

Laskar P, Somani S, Campbell S, Mullin M, Keating P, Tate R . Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells. Nanoscale. 2019; 11(42):20058-20071. DOI: 10.1039/c9nr07254c. View

20.

Iguarbe V, Concellon A, Termine R, Golemme A, Barbera J, Serrano J . Making Coaxial Wires Out of Janus Dendrimers for Efficient Charge Transport. ACS Macro Lett. 2022; 7(9):1138-1143. DOI: 10.1021/acsmacrolett.8b00505. View