Genetic Variations in Gene and Risk of Preeclampsia: A Pilot Study

Overview

Journal J Clin Med

Specialty General Medicine

Date 2023 Feb 25

PMID 36836041

Authors

Dong He

Xianglan Peng

Hongkai Xie

Rui Peng

Qixuan Li

Yitong Guo

Wei Wang

Hong He

Yang Chen

Affiliations

Soon will be listed here.

Abstract

Preeclampsia (PE) is a typical hypertensive disorders of pregnancy (HDP) which can cause substantial morbidity and mortality in both pregnant women and fetuses. The renin-angiotensin system (RAS) genes are the main HDP-causing genes, and Angiotensinogen (AGT) as the initial substrate can directly reflect the activity of the entire RAS. However, the association between SNPs and PE risk has rarely been confirmed. This study was carried out to determine whether SNPs could affect the risk of PE in 228 cases and 358 controls. The genotyping result revealed that the rs7079 TT carrier was related to increased PE risk. Further stratified analysis illustrated that the rs7079 TT genotype significantly increased the PE risk in subgroups of Age < 35, BMI < 25, Albumin (ALB) ≥ 30 and Aspartate aminotransferase (AST) < 30. These findings demonstrated that the rs7079 might be a promising candidate SNP strongly associated with PE susceptibility.

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