A New Model of the Mechanism Underlying Lead Poisoning: SNP in MiRNA Target Region Influence the AGT Expression Level

Overview

Journal Hereditas

Specialty Genetics

Date 2019 Feb 1

PMID 30700972

Citations 7

Authors

Yu Wu

Miaomiao Wang

Jinlong Zhang

Na Sun

Chunping Li

Affiliations

Soon will be listed here.

Abstract

Background: To determine if the rs7079 polymorphism located in the 3' UTR of the angiotensinogen gene () altered gene expression and the risk of lead poisoning. A case-control study and luciferase reporter gene assay identified a significant association between rs7079 variants and the risk of lead poisoning.

Results: Serum AGT levels were significantly higher in individuals carrying the rs7079 CA genotype, as compared to those carrying the rs7079 CC genotype. The binding of the miRNA mimics miR-31-5p and miR-584-5p to the 3' UTR of differed based on which rs7079 variant was present, implying that gene expression depends on the rs7079 variant carried.

Conclusions: The rs7079 C to A substitution reduced the binding of miR-31-5p/miR-584-5p to the 3' UTR of , possibly altering the risk of lead poisoning.

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