Effect of the Rho-Kinase/ROCK Signaling Pathway on Cytoskeleton Components

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2023 Feb 25

PMID 36833199

Authors

Guangzhao Guan

Richard D Cannon

Dawn E Coates

Li Mei

Affiliations

Soon will be listed here.

Abstract

The mechanical properties of cells are important in tissue homeostasis and enable cell growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties are determined to a large extent by the cytoskeleton. The cytoskeleton is a complex and dynamic network composed of microfilaments, intermediate filaments and microtubules. These cellular structures confer both cell shape and mechanical properties. The architecture of the networks formed by the cytoskeleton is regulated by several pathways, a key one being the Rho-kinase/ROCK signaling pathway. This review describes the role of ROCK (Rho-associated coiled-coil forming kinase) and how it mediates effects on the key components of the cytoskeleton that are critical for cell behaviour.

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