» Articles » PMID: 36832767

The Potential Therapeutic Role of for Treatment of Inflammatory Bowel Disease

Overview
Journal Foods
Specialty Biotechnology
Date 2023 Feb 25
PMID 36832767
Authors
Affiliations
Soon will be listed here.
Abstract

Inflammatory bowel disease (IBD) is a heterogeneous group of diseases associated with chronic inflammation of the intestinal tract, and is highly prevalent worldwide. Although its origin is not yet fully understood, new evidence emphasizes that environmental factors, especially dietary factors and intestinal microbiota disorders are key triggers of IBD. Probiotics, such as spp., play an essential role in human health as they exert beneficial effects on the composition of the human gastrointestinal microbial community and immune system. Probiotic-based therapies have been shown to be effective in alleviating IBD. Among these, is one of the most widely used strains. is widely present in the intestines of healthy individuals; it regulates the intestinal immune system and reduces inflammation through a variety of mechanisms. The purpose of this study was to identify scientific evidence related to and IBD, review and summarize the results, and discuss the possible mechanisms of action as a starting point for future research on IBD treatment.

Citing Articles

Restore intestinal steady-state: new advances in the clinical management of chemotherapy-associated diarrhea and constipation.

Chen M, Li Y, Chen P J Mol Histol. 2025; 56(2):101.

PMID: 40056250 PMC: 11890403. DOI: 10.1007/s10735-025-10367-w.


Probiotic Characterization of Lactic Acid Bacteria from Donkey Feces in China.

Wu Y, Yue S, Yu J, Bian F, Chen G, Zhang Y Animals (Basel). 2025; 15(2).

PMID: 39858207 PMC: 11758317. DOI: 10.3390/ani15020207.


Bacillus licheniformis B410 Alleviates Inflammation Induced by Lipopolysaccharide and Salmonella by Inhibiting NF-κB and IRF Signaling Pathways in Macrophages.

Xiong D, Sun T, Liu M, Wang B, Guan T, Song L Probiotics Antimicrob Proteins. 2024; .

PMID: 39739164 DOI: 10.1007/s12602-024-10440-y.


Gut-Brain Axis and Neuroinflammation: The Role of Gut Permeability and the Kynurenine Pathway in Neurological Disorders.

Kearns R Cell Mol Neurobiol. 2024; 44(1):64.

PMID: 39377830 PMC: 11461658. DOI: 10.1007/s10571-024-01496-z.


Paraprobiotic derived from GV1 improves immune response and gut microbiota composition in cyclophosphamide-treated immunosuppressed mice.

Lee H, Tran M, Le M, Justine E, Kim Y Front Immunol. 2024; 15:1285063.

PMID: 38455053 PMC: 10918466. DOI: 10.3389/fimmu.2024.1285063.


References
1.
Fedorak R, Feagan B, Hotte N, Leddin D, Dieleman L, Petrunia D . The probiotic VSL#3 has anti-inflammatory effects and could reduce endoscopic recurrence after surgery for Crohn's disease. Clin Gastroenterol Hepatol. 2014; 13(5):928-35.e2. DOI: 10.1016/j.cgh.2014.10.031. View

2.
von Ossowski I, Reunanen J, Satokari R, Vesterlund S, Kankainen M, Huhtinen H . Mucosal adhesion properties of the probiotic Lactobacillus rhamnosus GG SpaCBA and SpaFED pilin subunits. Appl Environ Microbiol. 2010; 76(7):2049-57. PMC: 2849237. DOI: 10.1128/AEM.01958-09. View

3.
Liu Z, Liu F, Wang W, Sun C, Gao D, Ma J . Study of the alleviation effects of a combination of Lactobacillus rhamnosus and inulin on mice with colitis. Food Funct. 2020; 11(5):3823-3837. DOI: 10.1039/c9fo02992c. View

4.
Lin P, Myers L, Ray L, Song S, Nasr T, Berardinelli A . Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Radic Biol Med. 2009; 47(8):1205-11. PMC: 2760264. DOI: 10.1016/j.freeradbiomed.2009.07.033. View

5.
Celiberto L, Bedani R, Rossi E, Cavallini D . Probiotics: The scientific evidence in the context of inflammatory bowel disease. Crit Rev Food Sci Nutr. 2015; 57(9):1759-1768. DOI: 10.1080/10408398.2014.941457. View