Immune Mechanisms of Group B Coxsackievirus Induced Viral Myocarditis

Overview

Journal Virulence

Specialty Microbiology

Date 2023 Feb 24

PMID 36827455

Authors

Yue Zhang

Xiaobin Zhou

Shuyi Chen

Xinchen Sun

Chenglin Zhou

Affiliations

Soon will be listed here.

Abstract

Viral myocarditis is known to be a primary cause of dilated cardiomyopathy (DCM) that can lead to heart failure and sudden cardiac death and is invariably caused by myocardial viral infection following active inflammatory destruction of the myocardium. Although acute viral myocarditis frequently recovers on its own, current chronic myocarditis therapies are unsatisfactory, where the persistence of viral or immunological insults to the heart may play a role. Cellular and mouse experimental models that utilized the most prevalent Coxsackievirus group B type 3 (CVB3) virus infection causing myocarditis have illustrated the pathophysiology of viral myocarditis. In this review, immunological insights into the different stages of development of viral myocarditis were discussed, concentrating on the mechanisms of innate and adaptive immunity in the development of CVB3-induced myocarditis.

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