The First Reference Genome Provides a Resource for Investigating the Genetic Basis of Semelparity and Age-related Neuropathologies

Overview

Journal GigaByte

Date 2023 Feb 24

PMID 36824596

Authors

Parice A Brandies

Simon Tang

Robert S P Johnson

Carolyn J Hogg

Katherine Belov

Affiliations

Soon will be listed here.

Abstract

Antechinus are a genus of mouse-like marsupials that exhibit a rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for the brown antechinus (). The reference genome is 3.3 Gb in size with a scaffold N50 of 73Mb and 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds to chromosomes and identify 0.78 Mb of Y-chromosome scaffolds. Comparative genomics revealed interesting expansions in the NMRK2 gene and the protocadherin gamma family, which have previously been associated with aging and age-related dementias respectively. Transcriptome data displayed expression of common Alzheimer's related genes in the antechinus brain and highlight the potential of utilising the antechinus as a future disease model. The valuable genomic resources provided herein will enable future research to explore the genetic basis of semelparity and age-related processes in the antechinus.

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