Epigenetic Markers in the Embryonal Germ Cell Development and Spermatogenesis

Overview

Journal Basic Clin Androl

Publisher Biomed Central

Date 2023 Feb 23

PMID 36814207

Authors

Amadeusz Odroniec

Marta Olszewska

Maciej Kurpisz

Affiliations

Soon will be listed here.

Abstract

Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis. During spermatogenesis, key spermatogenic events such as stem cell self-renewal and commitment to meiosis, meiotic recombination, meiotic sex chromosome inactivation, followed by cellular and chromatin remodeling of elongating spermatids occur, leading to sperm cell production. All the mentioned events are at least partially controlled by the epigenetic modifications of DNA and histones. Additionally, during embryonal development in primordial germ cells, global epigenetic reprogramming of DNA occurs. In this review, we summarized the most important epigenetic modifications in the particular stages of germ cell development, in DNA and histone proteins, starting from primordial germ cells, during embryonal development, and ending with histone-to-protamine transition during spermiogenesis.

Citing Articles

Research progress on the fanconi anemia signaling pathway in non-obstructive azoospermia.

Xu H, Zhang Y, Wang C, Fu Z, Lv J, Yang Y Front Endocrinol (Lausanne). 2024; 15:1393111.

PMID: 38846492 PMC: 11153779. DOI: 10.3389/fendo.2024.1393111.

Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice.

Fofana M, Li Z, Li H, Li W, Wu L, Lu L Toxics. 2024; 12(4).

PMID: 38668519 PMC: 11055147. DOI: 10.3390/toxics12040296.

When Dad's Stress Gets under Kid's Skin-Impacts of Stress on Germline Cargo and Embryonic Development.

Kretschmer M, Fischer V, Gapp K Biomolecules. 2023; 13(12).

PMID: 38136621 PMC: 10742275. DOI: 10.3390/biom13121750.

Epigenetic Reprogramming in and : From Fertilization to Primordial Germ Cell Development.

Singh A, Rappolee D, Ruden D Cells. 2023; 12(14).

PMID: 37508536 PMC: 10377882. DOI: 10.3390/cells12141874.

References

Ioannou D, Miller D, Griffin D, Tempest H . Impact of sperm DNA chromatin in the clinic. J Assist Reprod Genet. 2015; 33(2):157-66. PMC: 4758997. DOI: 10.1007/s10815-015-0624-x. View

Myrick D, Christopher M, Scott A, Simon A, Donlin-Asp P, Kelly W . KDM1A/LSD1 regulates the differentiation and maintenance of spermatogonia in mice. PLoS One. 2017; 12(5):e0177473. PMC: 5428937. DOI: 10.1371/journal.pone.0177473. View

Bell E, Nagamori I, Williams E, Del Rosario A, Bryson B, Watson N . SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development. 2014; 141(18):3495-504. PMC: 4197722. DOI: 10.1242/dev.110627. View

Uysal F, Akkoyunlu G, Ozturk S . DNA methyltransferases exhibit dynamic expression during spermatogenesis. Reprod Biomed Online. 2016; 33(6):690-702. DOI: 10.1016/j.rbmo.2016.08.022. View

Bennett D, Yu L, Yang J, Srivastava G, Aubin C, De Jager P . Epigenomics of Alzheimer's disease. Transl Res. 2014; 165(1):200-20. PMC: 4233194. DOI: 10.1016/j.trsl.2014.05.006. View

Lambrot R, Siklenka K, Lafleur C, Kimmins S . The genomic distribution of histone H3K4me2 in spermatogonia is highly conserved in sperm†. Biol Reprod. 2019; 100(6):1661-1672. DOI: 10.1093/biolre/ioz055. View

Miller D, Brinkworth M, Iles D . Paternal DNA packaging in spermatozoa: more than the sum of its parts? DNA, histones, protamines and epigenetics. Reproduction. 2009; 139(2):287-301. DOI: 10.1530/REP-09-0281. View

Mulder M, Witting K, Ovaa H . Cracking the Ubiquitin Code: The Ubiquitin Toolbox. Curr Issues Mol Biol. 2019; 37:1-20. DOI: 10.21775/cimb.037.001. View

Krishnamoorthy T, Chen X, Govin J, Cheung W, Dorsey J, Schindler K . Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Genes Dev. 2006; 20(18):2580-92. PMC: 1578680. DOI: 10.1101/gad.1457006. View

10.

Gong F, Miller K . Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation. Mutat Res. 2013; 750(1-2):23-30. DOI: 10.1016/j.mrfmmm.2013.07.002. View

11.

Krausz C, Riera-Escamilla A . Genetics of male infertility. Nat Rev Urol. 2018; 15(6):369-384. DOI: 10.1038/s41585-018-0003-3. View

12.

Yang J, Bashkenova N, Zang R, Huang X, Wang J . The roles of TET family proteins in development and stem cells. Development. 2020; 147(2). PMC: 6983710. DOI: 10.1242/dev.183129. View

13.

Lu L, Wu J, Ye L, Gavrilina G, Saunders T, Yu X . RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Dev Cell. 2010; 18(3):371-84. PMC: 2840054. DOI: 10.1016/j.devcel.2010.01.010. View

14.

Maeda I, Okamura D, Tokitake Y, Ikeda M, Kawaguchi H, Mise N . Max is a repressor of germ cell-related gene expression in mouse embryonic stem cells. Nat Commun. 2013; 4:1754. DOI: 10.1038/ncomms2780. View

15.

Collins R, Tachibana M, Tamaru H, Smith K, Jia D, Zhang X . In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases. J Biol Chem. 2004; 280(7):5563-70. PMC: 2696276. DOI: 10.1074/jbc.M410483200. View

16.

Blanco Rodriguez J, Camprubi Sanchez C . Epigenetic Transgenerational Inheritance. Adv Exp Med Biol. 2019; 1166:57-74. DOI: 10.1007/978-3-030-21664-1_4. View

17.

Kaushik A, Bhartiya D . Testicular cancer in mice: interplay between stem cells and endocrine insults. Stem Cell Res Ther. 2022; 13(1):243. PMC: 9175365. DOI: 10.1186/s13287-022-02784-5. View

18.

Wei J, Huang K, Yang C, Kang C . Non-coding RNAs as regulators in epigenetics (Review). Oncol Rep. 2016; 37(1):3-9. DOI: 10.3892/or.2016.5236. View

19.

Peixoto P, Cartron P, Serandour A, Hervouet E . From 1957 to Nowadays: A Brief History of Epigenetics. Int J Mol Sci. 2020; 21(20). PMC: 7588895. DOI: 10.3390/ijms21207571. View

20.

Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y . The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells. Cell. 2015; 161(6):1437-52. DOI: 10.1016/j.cell.2015.05.015. View