Drug Delivery Systems Based on Polyethylene Glycol Hydrogels for Enhanced Bone Regeneration

Overview

Journal Front Bioeng Biotechnol

Date 2023 Feb 16

PMID 36793443

Authors

Shouye Sun

Yutao Cui

Baoming Yuan

Minghan Dou

Gan Wang

Hang Xu

Jingwei Wang

Wen Yin

Dankai Wu

Chuangang Peng

Affiliations

Soon will be listed here.

Abstract

Drug delivery systems composed of osteogenic substances and biological materials are of great significance in enhancing bone regeneration, and appropriate biological carriers are the cornerstone for their construction. Polyethylene glycol (PEG) is favored in bone tissue engineering due to its good biocompatibility and hydrophilicity. When combined with other substances, the physicochemical properties of PEG-based hydrogels fully meet the requirements of drug delivery carriers. Therefore, this paper reviews the application of PEG-based hydrogels in the treatment of bone defects. The advantages and disadvantages of PEG as a carrier are analyzed, and various modification methods of PEG hydrogels are summarized. On this basis, the application of PEG-based hydrogel drug delivery systems in promoting bone regeneration in recent years is summarized. Finally, the shortcomings and future developments of PEG-based hydrogel drug delivery systems are discussed. This review provides a theoretical basis and fabrication strategy for the application of PEG-based composite drug delivery systems in local bone defects.

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