Respiratory Infections and Type 1 Diabetes: Potential Roles in Pathogenesis

Overview

Journal Rev Med Virol

Publisher Wiley

Specialty Microbiology

Date 2023 Feb 15

PMID 36790804

Authors

Roy Wu

Mohsin Mumtaz

Anna J Maxwell

Sonia R Isaacs

Jutta E Laiho

William D Rawlinson

Heikki Hyoty

Maria E Craig

Ki Wook Kim

Affiliations

Soon will be listed here.

Abstract

Among the environmental factors associated with type 1 diabetes (T1D), viral infections of the gut and pancreas has been investigated most intensely, identifying enterovirus infections as the prime candidate trigger of islet autoimmunity (IA) and T1D development. However, the association between respiratory tract infections (RTI) and IA/T1D is comparatively less known. While there are significant amounts of epidemiological evidence supporting the role of respiratory infections in T1D, there remains a paucity of data characterising infectious agents at the molecular level. This gap in the literature precludes the identification of the specific infectious agents driving the association between RTI and T1D. Furthermore, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the development of IA/T1D remains undeciphered. Here, we provide a comprehensive overview of the evidence to date, implicating RTIs (viral and non-viral) as potential risk factors for IA/T1D.

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Respiratory infections and type 1 diabetes: Potential roles in pathogenesis.

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