The Prevention Effect of Lactobacillus Plantarum 17-5 on Escherichia Coli-Induced Mastitis in Mice

Overview

Journal Probiotics Antimicrob Proteins

Publisher Springer

Specialties Infectious Diseases
Microbiology
Nutritional Sciences
Pharmacology

Date 2023 Feb 15

PMID 36790662

Authors

Ke Li

Ming Yang

Li Jia

Mengyue Tian

Jinliang Du

Yinghao Wu

Lining Yuan

Lianmin Li

Yuzhong Ma

Affiliations

Soon will be listed here.

Abstract

Mastitis is the most economically important disease affecting the dairy industry worldwide. Lactobacillus plantarum, an important probiotic with a wide range of applications, has potential anti-inflammatory properties and has become a currently strong candidate for mastitis therapies. In the current study, we evaluated the prevention effect of Lactobacillus plantarum 17-5 on Escherichia coli-induced mastitis in mice. The results showed that pretreatment with L. plantarum 17-5 maintained the integrity of tight junctions; improved inflammatory injury; decreased MPO activity and the mRNA expression levels of IL1β, IL6, and TNFα; and inhibited the NF-κB and MAPK signaling pathways in mice mammary tissue. The results indicated that Lactobacillus plantarum 17-5 had excellent anti-inflammatory activities and could be developed into microecological preparation for clinical use to prevent mastitis.

Citing Articles

Bioactive Compounds and Probiotics Mitigate Mastitis by Targeting NF-κB Signaling Pathway.

Khan M, Li L, Wang T, Liu X, Chen W, Ma Q Biomolecules. 2024; 14(8).

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In vitro characterization of probiotic potential of Lactobacillus plantarum CM49 against selected cattle mastitogens.

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