Maternal Nutritional Status and Milk Volume and Composition in India: an Observational Study

Overview

Journal Am J Clin Nutr

Publisher Elsevier

Specialty Nutritional Sciences

Date 2023 Feb 11

PMID 36773786

Authors

Melissa F Young

Emily C Faerber

Rukshan V Mehta

Samriddhi Ranjan

Sweekruthi A Shetty

Usha Ramakrishnan

Kannan Rangiah

Beena Bose

Sarita Devi

Pratibha Dwarkanath

Anura V Kurpad

Sunita Taneja

Reynaldo Martorell

Affiliations

Soon will be listed here.

Abstract

Background: Human milk provides essential nutrition for infants, and its benefits are well established. We lack data on the influence of maternal nutritional status on milk volume and composition in low-middle income countries.

Objective: We aimed to 1) assess lactation performance (human milk volume, macronutrient composition, and infant energy intake) in Indian females and 2) examine the associations between maternal anthropometry (BMI, percentage body fat) and lactation performance.

Methods: We conducted an observational study among 232 mother-infant dyads, 2 to 4 mo postpartum in Haryana, India. We used deuterium oxide dose-to-mother technique to measure milk volume and maternal percentage body fat and collected human milk samples to determine macronutrient and energy concentrations. Adjusted multiple linear regression models were used to examine the associations between maternal anthropometry and lactation performance.

Results: The mean BMI and percentage body fat of mothers were 21.7 ± 3.6 kg/m and 29.5 ± 7.7, respectively. Milk volume and macronutrient composition were similar to the reference values (means ± standard deviations: milk volume, 724 ± 184 mL/d; median (25th, 75th percentile); protein, 9.9 (8.3, 11.7) g/L; fat, 41.0 ± 15.2 g/L; energy density, 0.71 ± 0.14 kcal/g; lactose, 65.5 (55.3, 71.3) g/L). Maternal BMI and percentage body fat were not significantly associated with macronutrient composition. Both maternal BMI and percentage body fat were negatively associated with milk volume (-7.0, 95% CI: -12.4, -1.6 mL/d; -3.5, 95% CI: -6.0, -1.1mL/d, respectively) but there were no effects on the total energy intake of infants after adjusting for covariates.

Conclusion: Most mothers had a normal BMI and milk of similar composition and volume to reference values. Future work in populations with a greater burden of underweight and/or obesity are needed to examine the underlying mechanisms between maternal body composition and milk volume. This trial was registered at The Clinical Trials Registry- India as CTRI/2017/01/007636.

Citing Articles

Nutrient composition of human milk of Indian mothers: relation with maternal and infant anthropometry.

Kumari-Maurya S, Annapure U, Gupta S J Food Sci Technol. 2025; 62(2):273-282.

PMID: 39868392 PMC: 11757815. DOI: 10.1007/s13197-024-06025-w.

The Deuterium Oxide Dilution Method to Quantify Human Milk Intake Volume of Infants: A Systematic Review-A Contribution from the ConcePTION Project.

Cloostermans L, Allegaert K, Smits A, Van Neste M Nutrients. 2024; 16(23).

PMID: 39683598 PMC: 11644218. DOI: 10.3390/nu16234205.

Human Milk Nutrient Composition Data is Critically Lacking in the United States and Canada: Results from a Systematic Scoping Review of 2017-2022.

Mohr A, Senkus K, McDermid J, Berger P, Perrin M, Handu D Adv Nutr. 2023; 14(6):1617-1632.

PMID: 37758059 PMC: 10721511. DOI: 10.1016/j.advnut.2023.09.007.

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