Metabolomic Profiling, Antibacterial, and Molluscicidal Properties of the Medicinal Plants and : In Silico Molecular Docking Study

Overview

Journal Plants (Basel)

Date 2023 Feb 11

PMID 36771561

Authors

Mostafa Y Morad

Heba El-Sayed

Manal F El-Khadragy

Asmaa Abdelsalam

Eman Zakaria Ahmed

Amina M Ibrahim

Affiliations

Soon will be listed here.

Abstract

The potential of plant-based natural compounds in the creation of new molluscicidal and antimicrobial medications has gained attention in recent years. The current study compared the metabolic profiles, antibacterial, and molluscicidal properties of the medicinal plants () and (). In both plants, 118 metabolites were identified using gas chromatography-mass spectrometry. Palmitic acid, stigmasterol, and campesterol were the most prevalent constituents. extract showed stronger antibacterial activity than . against and . Both extracts exhibited molluscicidal activity against with LC values of (135 mg/L) and (223.8 mg/L). Survival rates of snails exposed to sub-lethal concentrations (LC) of and extracts were 5% and 20%, respectively. The hatchability of snail eggs exposed to both extracts has been dramatically reduced. Both extracts significantly decreased the levels of alkaline phosphatase, acid phosphatase, total protein, and albumin in snails, as well as causing DNA damage and resulting in numerous hermaphrodite and digestive gland damages and distortions. Molecular docking showed palmitic acid binding with acid, alkaline, and alanine aminotransferases in treated digestive gland snails. In conclusion, and have antibacterial and molluscicidal properties.

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