Antiaging and Anxiolytic Effects of Combinatory Formulas Based on Four Medicinal Herbs

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2017 May 2

PMID 28458714

Citations 5

Authors

Rui Li

Wingman Chan

Waikin Mat

Yiucheong Ho

Rigil K Yeung

Shuiying Tsang

Hong Xue

Affiliations

Soon will be listed here.

Abstract

The objective of the present study was to search for medicinal-herb combinations based on Radix DC ("B"), Rhizoma WT Wang ("Y"), Caulis Thunb ("P"), and Flos Durazz ("A") for antiaging, anxiolytic, and sedative effects. Application of the D-galactose induced accelerated-aging model employing male ICR mice showed that oral administration of some combinations of B, Y, P, and A significantly improved spatial memory in Y-maze test and reduced brain levels of tumor necrosis factor- and interleukin-6 based on immunoassays and oxidative stress marker malondialdehyde, based on the thiobarbituric acid test, and the loss of whiskers, indicating antiaging and antineurodegeneration effects. In addition, some of the combinatory formulas induced anxiolysis measured using the elevated plus-maze test and/or sedative effects measured using the hole-board test. Over the range of dosages examined, all possible combinations of the four herbs were devoid of any significant side effects in the form of altered locomotor activity, decreased muscle coordination, or anterograde amnesia assessed using the photobeam and rotarod and step-through passive avoidance methods, respectively. The results suggest that various combinations of the B, Y, P, and A herbs could be useful as nonsedative, antiaging and/or antineurodegenerative agents, or anxiolytic agents.

Citing Articles

Health-Promoting Activities and Associated Mechanisms of Polygonati Rhizoma Polysaccharides.

Wang S, He F, Wu H, Xiang F, Zheng H, Wu W Molecules. 2023; 28(3).

PMID: 36771015 PMC: 9919897. DOI: 10.3390/molecules28031350.

Use of Steaming Process to Improve Biochemical Activity of Polysaccharides against D-Galactose-Induced Memory Impairment in Mice.

Bian Z, Li C, Peng D, Wang X, Zhu G Int J Mol Sci. 2022; 23(19).

PMID: 36232521 PMC: 9570032. DOI: 10.3390/ijms231911220.

Ganoderma lucidum Rhodiola compound preparation prevent D-galactose-induced immune impairment and oxidative stress in aging rat model.

Yuan S, Yang Y, Li J, Tan X, Cao Y, Li S Sci Rep. 2020; 10(1):19244.

PMID: 33159105 PMC: 7648061. DOI: 10.1038/s41598-020-76249-1.

Traditional Chinese Medicine Jiuwei Zhenxin Granules in Treating Depression: An Overview.

Wang J, Wu X Neuropsychiatr Dis Treat. 2020; 16:2237-2255.

PMID: 33116523 PMC: 7541918. DOI: 10.2147/NDT.S273324.

Combination of chick embryo and nutrient mixture prevent D-galactose-induced cognitive deficits, immune impairment and oxidative stress in aging rat model.

Ma J, Wang H, Liu B, Shan Y, Zhou H, Qi X Sci Rep. 2019; 9(1):4092.

PMID: 30858562 PMC: 6411858. DOI: 10.1038/s41598-019-40953-4.

References

Heneka M, Carson M, El Khoury J, Landreth G, Brosseron F, Feinstein D . Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015; 14(4):388-405. PMC: 5909703. DOI: 10.1016/S1474-4422(15)70016-5. View

Goossens V, Grooten J, de Vos K, Fiers W . Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc Natl Acad Sci U S A. 1995; 92(18):8115-9. PMC: 41106. DOI: 10.1073/pnas.92.18.8115. View

Franceschi C, Campisi J . Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014; 69 Suppl 1:S4-9. DOI: 10.1093/gerona/glu057. View

Mantsch J, Li S, Risinger R, Awad S, Katz E, Baker D . Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats. Psychopharmacology (Berl). 2007; 192(4):581-91. DOI: 10.1007/s00213-007-0754-7. View

Ylinen A, Miettinen R, Pitkanen A, Gulyas A, Freund T, Riekkinen P . Enhanced GABAergic inhibition preserves hippocampal structure and function in a model of epilepsy. Proc Natl Acad Sci U S A. 1991; 88(17):7650-3. PMC: 52359. DOI: 10.1073/pnas.88.17.7650. View

Fernandez-Checa J, Fernandez A, Morales A, Mari M, Garcia-Ruiz C, Colell A . Oxidative stress and altered mitochondrial function in neurodegenerative diseases: lessons from mouse models. CNS Neurol Disord Drug Targets. 2010; 9(4):439-54. DOI: 10.2174/187152710791556113. View

Wong V, Zhang M, Zhou H, Ching Lam K, Chan P, Law C . Saikosaponin-d Enhances the Anticancer Potency of TNF-α via Overcoming Its Undesirable Response of Activating NF-Kappa B Signalling in Cancer Cells. Evid Based Complement Alternat Med. 2013; 2013:745295. PMC: 3610377. DOI: 10.1155/2013/745295. View

Zhu J, Mu X, Zeng J, Xu C, Liu J, Zhang M . Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. PLoS One. 2014; 9(6):e101291. PMC: 4076296. DOI: 10.1371/journal.pone.0101291. View

Heppner F, Ransohoff R, Becher B . Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015; 16(6):358-72. DOI: 10.1038/nrn3880. View

10.

Yang Z, Shao Y, Li S, Qi J, Zhang M, Hao W . Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot study. Acta Pharmacol Sin. 2008; 29(7):781-8. PMC: 4535343. DOI: 10.1111/j.1745-7254.2008.00817.x. View

11.

File S, Pellow S . The effects of triazolobenzodiazepines in two animal tests of anxiety and in the holeboard. Br J Pharmacol. 1985; 86(3):729-35. PMC: 1916742. DOI: 10.1111/j.1476-5381.1985.tb08952.x. View

12.

Xu S, Yu L, Han Y, Chen Y, Jin G . Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain. Zhongguo Yao Li Xue Bao. 1989; 10(2):104-10. View

13.

Wu L, Wang Y, Li Z, Zhang B, Cheng Y, Fan X . Identifying roles of "Jun-Chen-Zuo-Shi" component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology. Chin Med. 2014; 9:24. PMC: 4196468. DOI: 10.1186/1749-8546-9-24. View

14.

An F, Yang G, Tian J, Wang S . Antioxidant effects of the orientin and vitexin in Trollius chinensis Bunge in D-galactose-aged mice. Neural Regen Res. 2014; 7(33):2565-75. PMC: 4200723. DOI: 10.3969/j.issn.1673-5374.2012.33.001. View

15.

Chen J, Chang N, Chung J, Chen K . Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells. Am J Chin Med. 2003; 31(3):363-77. DOI: 10.1142/S0192415X03001065. View

16.

Kang T, Jeong S, Kim N, Higuchi R, Kim Y . Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin Durazz. J Ethnopharmacol. 2000; 71(1-2):321-3. DOI: 10.1016/s0378-8741(99)00202-0. View

17.

Perry G, Cash A, Smith M . Alzheimer Disease and Oxidative Stress. J Biomed Biotechnol. 2002; 2(3):120-123. PMC: 161361. DOI: 10.1155/S1110724302203010. View

18.

Jiang W . Therapeutic wisdom in traditional Chinese medicine: a perspective from modern science. Trends Pharmacol Sci. 2005; 26(11):558-63. DOI: 10.1016/j.tips.2005.09.006. View

19.

Huen M, Hui K, Leung J, Sigel E, Baur R, Wong J . Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. Biochem Pharmacol. 2003; 66(12):2397-407. DOI: 10.1016/j.bcp.2003.08.016. View

20.

Chen C, Lang S, Zuo P, Yang N, Wang X, Xia C . Effects of D-galactose on the expression of hippocampal peripheral-type benzodiazepine receptor and spatial memory performances in rats. Psychoneuroendocrinology. 2006; 31(7):805-11. DOI: 10.1016/j.psyneuen.2006.03.004. View