P38 MAPK and Radiotherapy: Foes or Friends?

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2023 Feb 11

PMID 36765819

Authors

Natalia Garcia-Flores

Jaime Jimenez-Suarez

Cristina Garnes-Garcia

Diego M Fernandez-Aroca

Sebastia Sabater

Ignacio Andres

Antonio Fernandez-Aramburo

Maria Jose Ruiz-Hidalgo

Borja Belandia

Ricardo Sanchez-Prieto

Francisco J Cimas

Affiliations

Soon will be listed here.

Abstract

Over the last 30 years, the study of the cellular response to ionizing radiation (IR) has increased exponentially. Among the various signaling pathways affected by IR, p38 MAPK has been shown to be activated both in vitro and in vivo, with involvement in key processes triggered by IR-mediated genotoxic insult, such as the cell cycle, apoptosis or senescence. However, we do not yet have a definitive clue about the role of p38 MAPK in terms of radioresistance/sensitivity and its potential use to improve current radiotherapy. In this review, we summarize the current knowledge on this family of MAPKs in response to IR as well as in different aspects related to radiotherapy, such as their role in the control of REDOX, fibrosis, and in the radiosensitizing effect of several compounds.

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