Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy After Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2023 Feb 11

PMID 36765546

Authors

Arthur Berger

Guillaume Perrod

Mathieu Pioche

Maximilien Barret

Elodie Cesbron-Metivier

Vincent Lepilliez

Marianne Hupe

Enrique Perez-Cuadrado-Robles

Franck Cholet

Augustin Daubigny

Charles Texier

Einas Abou Ali

Edouard Chabrun

Jeremie Jacques

Timothee Wallenhorst

Jean Baptiste Chevaux

Marion Schaefer

Christophe Cellier

Gabriel Rahmi

Affiliations

Soon will be listed here.

Abstract

Background: In case of high risk of lymph node invasion after endoscopic resection (ER) of superficial esophageal squamous cell carcinoma (SCC), adjuvant chemoradiotherapy (CRT) can be an alternative to surgery. We assessed long-term clinical outcomes of adjuvant therapy by CRT after non-curative ER for superficial SCC.

Methods: We performed a retrospective multicenter study. From April 1999 to April 2018, all consecutive patients who underwent ER for SCC with tumor infiltration beyond the muscularis mucosae were included.

Results: A total of 137 ER were analyzed. The overall nodal or metastatic recurrence-free survival rate at 5 years was 88% and specific recurrence-free survival rates at 5 years with and without adjuvant therapy were, respectively, 97.9% and 79.1% ( = 0.011). Independent factors for nodal and/or distal metastatic recurrence were age (HR = 1.075, = 0.031), Sm infiltration depth > 200 µm (HR = 4.129, = 0.040), and the absence of adjuvant CRT or surgery (HR = 11.322, = 0.029).

Conclusion: In this study, adjuvant therapy is associated with a higher recurrence-free survival rate at 5 years after non-curative ER. This result suggests this approach may be considered as an alternative to surgery in selected patients.

Citing Articles

Esophagectomy Versus Endoscopic Resection with Adjuvant Therapy for T1b/T2 Esophageal Cancer: A Systematic Review and Meta-Analysis.

Peters E, Robinson M, Patel N, Kidane B Cancers (Basel). 2025; 17(4).

PMID: 40002274 PMC: 11853579. DOI: 10.3390/cancers17040680.

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