Submucosal Invasive Depth Predicts Lymph Node Metastasis and Poor Prognosis in Submucosal Invasive Esophageal Squamous Cell Carcinoma

Overview

Journal Am J Clin Pathol

Publisher Oxford University Press

Specialty Pathology

Date 2017 Oct 26

PMID 29069275

Citations 7

Authors

Tomohiro Kadota

Tomonori Yano

Takeo Fujita

Hiroyuki Daiko

Satoshi Fujii

Affiliations

Soon will be listed here.

Abstract

Objectives: Lymph node metastasis (LNM) in submucosal invasive esophageal squamous cell carcinoma (SM-ESCC) is a prognostic factor. The aim of this study was to identify a histopathologic predictor of LNM in SM-ESCC.

Methods: In total, 108 patients who underwent an esophagectomy and lymph node dissection without preoperative therapy and who were pathologically diagnosed with SM-ESCC were enrolled in this study. Relationships between several clinicopathologic factors and LNM were examined.

Results: A multivariate analysis revealed that a tumor size of 35 mm or more (P = .0025), submucosal invasive depth (SID) of 2,000 μm or more (P = .013), and lymphatic infiltration (P < .0001) were significant independent predictors of LNM. In addition, there were significant differences in recurrence-free survival curves between patients with SID less than 2,000 μm or not (P = .029) and tumor size less than 35 mm or not (P = .049).

Conclusions: This study suggests that SID may predict not only LNM but also poor prognosis.

Citing Articles

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Fukuhara M, Urabe Y, Oka S, Ishibashi K, Konishi H, Mizuno J Esophagus. 2023; 20(3):541-547.

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Kato M, Hayashi Y, Uema R, Kimura K, Inoue T, Sakatani A JGH Open. 2020; 4(2):178-184.

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