Cell Senescence, Loss of Splicing, and Lipid Metabolism in TDP-43-related Neurodegenerative Processes

Overview

Journal Neural Regen Res

Date 2023 Feb 8

PMID 36751794

Authors

Pascual Torres

Reinald Pamplona

Manuel Portero-Otin

Affiliations

Soon will be listed here.

Citing Articles

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition.

Torres P, Rico-Rios S, Ceron-Codorniu M, Santacreu-Vilaseca M, Seoane-Miraz D, Jad Y Acta Neuropathol. 2024; 148(1):45.

PMID: 39305312 PMC: 11416411. DOI: 10.1007/s00401-024-02780-4.

Chronological and Biological Aging in Amyotrophic Lateral Sclerosis and the Potential of Senolytic Therapies.

Dashtmian A, Darvishi F, Arnold W Cells. 2024; 13(11.

PMID: 38891059 PMC: 11171952. DOI: 10.3390/cells13110928.

References

Torres P, Anerillas C, Ramirez-Nunez O, Fernandez A, Encinas M, Povedano M . A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers. Dis Model Mech. 2022; 15(8). PMC: 9459393. DOI: 10.1242/dmm.049059. View

Flor A, Wolfgeher D, Wu D, Kron S . A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence. Cell Death Discov. 2017; 3:17075. PMC: 5661608. DOI: 10.1038/cddiscovery.2017.75. View

Cacabelos D, Ayala V, Granado-Serrano A, Jove M, Torres P, Boada J . Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis. Neurobiol Dis. 2016; 88:148-60. DOI: 10.1016/j.nbd.2016.01.007. View

Marschallinger J, Iram T, Zardeneta M, Lee S, Lehallier B, Haney M . Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Nat Neurosci. 2020; 23(2):194-208. PMC: 7595134. DOI: 10.1038/s41593-019-0566-1. View

Shimabukuro M, Langhi L, Cordeiro I, Brito J, Batista C, Mattson M . Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes. Sci Rep. 2016; 6:23795. PMC: 4814830. DOI: 10.1038/srep23795. View

Egawa N, Izumi Y, Suzuki H, Tsuge I, Fujita K, Shimano H . TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2. Sci Rep. 2022; 12(1):7988. PMC: 9107471. DOI: 10.1038/s41598-022-12133-4. View

Ho W, Chang J, Lim K, Cazenave-Gassiot A, Nguyen A, Foo J . TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination. J Cell Biol. 2021; 220(9). PMC: 8348376. DOI: 10.1083/jcb.201910213. View

Ruiz M, Stahlman M, Boren J, Pilon M . AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin. J Lipid Res. 2019; 60(5):995-1004. PMC: 6495173. DOI: 10.1194/jlr.M092494. View

Torres P, Ramirez-Nunez O, Romero-Guevara R, Bares G, Granado-Serrano A, Ayala V . Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue. Autophagy. 2018; 14(8):1398-1403. PMC: 6103657. DOI: 10.1080/15548627.2018.1474311. View

10.

Volkmar N, Gawden-Bone C, Williamson J, Nixon-Abell J, West J, George-Hyslop P . Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2. EMBO J. 2022; 41(19):e110777. PMC: 9531299. DOI: 10.15252/embj.2022110777. View

11.

Ferrer I . Diversity of astroglial responses across human neurodegenerative disorders and brain aging. Brain Pathol. 2017; 27(5):645-674. PMC: 8029391. DOI: 10.1111/bpa.12538. View

12.

Ramirez-Nunez O, Jove M, Torres P, Sol J, Fontdevila L, Romero-Guevara R . Nuclear lipidome is altered in amyotrophic lateral sclerosis: A pilot study. J Neurochem. 2021; 158(2):482-499. DOI: 10.1111/jnc.15373. View

13.

Liu B, Wang X, Cao J, Chen L, Wang Y, Zhao B . TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma. Commun Biol. 2022; 5(1):816. PMC: 9376094. DOI: 10.1038/s42003-022-03788-w. View