Relationship Between Cefamandole and Cefuroxime Activity Against Oxacillin-resistant Staphylococcus Epidermidis and Oxacillin Resistance Phenotype

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1987 Sep 1

PMID 3674845

Citations 5

Authors

G L Woods

C C Knapp

J A Washington 2nd

Affiliations

Soon will be listed here.

Abstract

The activity of cefamandole and cefuroxime against oxacillin-resistant staphylococcus epidermidis was studied in vitro to determine whether there was any relationship between oxacillin resistance phenotypes and cephalosporin activity. Oxacillin resistance phenotypes were determined by efficiency-of-plating studies on Mueller-Hinton agar containing oxacillin, with and without NaCl, and incubated at 30 and 35 degrees C. On the basis of MIC and MBC determinations, cefamandole was more active than cefuroxime against oxacillin-resistant S. epidermidis. Although temperature had minimal effect on the activity of either cefamandole or cefuroxime, NaCl significantly decreased the activity of cefuroxime but not of cefamandole. Neither cephalosporin consistently produced greater than or equal to 99.9% bactericidal activity within 24 h in timed killing-curve studies. No consistent relationship was observed between cefamandole or cefuroxime activity and oxacillin resistance phenotype.

Citing Articles

Characterization of resistance phenotype and cephalosporin activity in oxacillin-resistant Staphylococcus aureus.

Knapp C, Washington 2nd J Antimicrob Agents Chemother. 1988; 32(2):170-4.

PMID: 3364941 PMC: 172129. DOI: 10.1128/AAC.32.2.170.

Bactericidal activity of oxacillin against beta-lactamase-hyperproducing Staphylococcus aureus.

Woods G, Yam P Antimicrob Agents Chemother. 1988; 32(11):1614-8.

PMID: 3266987 PMC: 175938. DOI: 10.1128/AAC.32.11.1614.

Salt-supplemented medium for testing methicillin-resistant staphylococci with newer beta-lactams.

Jorgensen J, REDDING J, Maher L, Ramirez P J Clin Microbiol. 1988; 26(9):1675-8.

PMID: 3183016 PMC: 266694. DOI: 10.1128/jcm.26.9.1675-1678.1988.

Reappraisal of the antistaphylococcal activities of first-generation (narrow-spectrum) and second-generation (expanded-spectrum) cephalosporins.

Sabath L Antimicrob Agents Chemother. 1989; 33(4):407-11.

PMID: 2658789 PMC: 172450. DOI: 10.1128/AAC.33.4.407.

Inoculum effect on growth-delay time of oxacillin-resistant strains of Staphylococcus aureus and Staphylococcus epidermidis exposed to cefamandole, cefazolin, and cefuroxime.

Yourassowsky E, Linden M, Crokaert F Antimicrob Agents Chemother. 1990; 34(4):505-9.

PMID: 2344158 PMC: 171633. DOI: 10.1128/AAC.34.4.505.

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