Emerging Roles of Microglia in Blood-Brain Barrier Integrity in Aging and Neurodegeneration

Overview

Journal Curr Neuropharmacol

Publisher Bentham Science Publishers

Date 2023 Feb 6

PMID 36740799

Authors

Simeng Zhang

Rui Meng

Muzhou Jiang

Hong Qing

Junjun Ni

Affiliations

Soon will be listed here.

Abstract

The blood-brain barrier (BBB) is a highly selective interface between the blood and the brain parenchyma. It plays an essential role in maintaining a specialized environment for central nervous system function and homeostasis. The BBB disrupts with age, which contributes to the development of many age-related disorders due to central and peripheral toxic factors or BBB dysfunction. Microglia, the resident innate immune cells of the brain, have recently been explored for their ability to directly and indirectly regulate the integrity of the BBB. This review will focus on the current understanding of the molecular mechanisms utilized by microglia to regulate BBB integrity and how this becomes disrupted in aging and age-associated diseases. We will also discuss the rationale for considering microglia as a therapeutic target to prevent or slow down neurodegeneration.

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