Non-Aquaporin Water Channels

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2023 Jan 30

PMID 36717505

Authors

Boyue Huang

Hongkai Wang

Baoxue Yang

Affiliations

Soon will be listed here.

Abstract

Water transport through membrane is so intricate that there are still some debates. AQPs are entirely accepted to allow water transmembrane movement depending on osmotic gradient. Cotransporters and uniporters, however, are also concerned in water homeostasis. UT-B has a single-channel water permeability that is similar to AQP1. CFTR was initially thought as a water channel but now not believed to transport water directly. By cotransporters, such as KCC4, NKCC1, SGLT1, GAT1, EAAT1, and MCT1, water is transported by water osmosis coupling with substrates, which explains how water is transported across the isolated small intestine. This chapter provides information about water transport mediated by other membrane proteins except AQPs.

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