Impact of Multidomain Preventive Strategies on Functional Brain Connectivity in Older Adults with Cognitive Complaint: Subset from the Montpellier Center of the Ancillary MAPT-MRI Study

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2023 Jan 27

PMID 36705622

Authors

Lisa Perus

Jean-Francois Mangin

Jeremy Deverdun

Laure-Anne Gutierrez

Emmanuelle Gourieux

Clara Fischer

Liesjet E H van Dokkum

Clara Manesco

Germain Busto

Sophie Guyonnet

Bruno Vellas

Audrey Gabelle

Emmanuelle Le Bars

Affiliations

Soon will be listed here.

Abstract

Introduction: The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC).

Methods: To determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints.

Results: No global change in FC was detected after uni or multidomain preventive interventions. However, an effect of omega-3 fatty acid supplementation dependent on cognitive decline status was underlined for frontoparietal, salience, visual and sensorimotor networks FC. These findings were independent of the cortical thickness and vascular burden.

Discussion: These results emphasize the importance of patient stratification, based on risk factors, for preventive interventions.

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