Chemiluminescent Polymeric Nanoprobes for Tumor Diagnosis: A Mini Review

Overview

Journal Front Chem

Specialty Chemistry

Date 2023 Jan 26

PMID 36700072

Authors

Xiaoyan Zhang

Cong Li

Wenjuan Chen

Guanhua Wang

Huiru Zou

Hao Liu

Affiliations

Soon will be listed here.

Abstract

Chemiluminescence (CL), a distinct luminescent process by taking advantage of chemical reactions rather than external light source, has recently attracted considerable research interests due to its high sensitivity and low background signal. The sensitivity and specificity of chemiluminescent signals in complex tumor microenvironment provide a sound basis for accurate detection of tumors. Various chemiluminescent nanoprobes with superior performance have been obtained by structural modification of chemiluminescent units or introduction of fluorescent dyes. In this review, we focused on the recent progress of chemiluminescent polymeric systems based on various chromophore substrates, including luminol, peroxyoxalates, 1, 2-dioxetanes and their derivatives for tumor detecting. And we also emphasized the design strategies, mechanisms and diagnostic applications of representative chemiluminescent polymeric nanoprobes. Finally, the critical challenges and perspectives of chemiluminescent systems usage in tumor diagnosis were also discussed.

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