The Critical Role of Cardiolipin in Metazoan Differentiation, Development, and Maturation

Overview

Journal Dev Dyn

Publisher Wiley

Specialty Anatomy & Histology

Date 2023 Jan 24

PMID 36692477

Authors

Melissa Olivar-Villanueva

Mindong Ren

Michael Schlame

Colin K L Phoon

Affiliations

Soon will be listed here.

Abstract

Cardiolipins are phospholipids that are central to proper mitochondrial functioning. Because mitochondria play crucial roles in differentiation, development, and maturation, we would also expect cardiolipin to play major roles in these processes. Indeed, cardiolipin has been implicated in the mechanism of three human diseases that affect young infants, implying developmental abnormalities. In this review, we will: (1) Review the biology of cardiolipin; (2) Outline the evidence for essential roles of cardiolipin during organismal development, including embryogenesis and cell maturation in vertebrate organisms; (3) Place the role(s) of cardiolipin during embryogenesis within the larger context of the roles of mitochondria in development; and (4) Suggest avenues for future research.

Citing Articles

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