Tau As a Fluid Biomarker of Concussion and Neurodegeneration

Overview

Journal Concussion

Date 2023 Jan 23

PMID 36687115

Authors

Iftakher Hossain

Kaj Blennow

Jussi P Posti

Henrik Zetterberg

Affiliations

Soon will be listed here.

Abstract

Concussion is predominant among the vast number of traumatic brain injuries that occur worldwide. Difficulties in timely identification, whether concussion led to neuronal injury or not, diagnosis and the lack of prognostic tools for adequate management could lead this type of brain injury to progressive neurodegenerative diseases. Tau has been extensively studied in recent years, particularly in repetitive mild traumatic brain injuries and sports-related concussions. Tauopathies, the group of neurodegenerative diseases, have also been studied with advanced functional imaging. Nevertheless, neurodegenerative diseases, such as chronic traumatic encephalopathy, are still conclusively diagnosed at autopsy. Here, we discuss the diagnostic dilemma and the relationship between concussion and neurodegenerative diseases and review the literature on tau as a promising biomarker for concussion.

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