Aquaporin-mediated Dysregulation of Cell Migration in Disease States

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2023 Jan 22

PMID 36682037

Authors

Ian M Smith

Shohini Banerjee

Allison K Moses

Kimberly M Stroka

Affiliations

Soon will be listed here.

Abstract

Dysregulated cell migration and invasion are hallmarks of many disease states. This dysregulated migratory behavior is influenced by the changes in expression of aquaporins (AQPs) that occur during pathogenesis, including conditions such as cancer, endometriosis, and arthritis. The ubiquitous function of AQPs in migration of diseased cells makes them a crucial target for potential therapeutics; this possibility has led to extensive research into the specific mechanisms underlying AQP-mediated diseased cell migration. The functions of AQPs depend on a diverse set of variables including cell type, AQP isoform, disease state, cell microenvironments, and even the subcellular localization of AQPs. To consolidate the considerable work that has been conducted across these numerous variables, here we summarize and review the last decade's research covering the role of AQPs in the migration and invasion of cells in diseased states.

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References

Chen Q, Zhu L, Zheng B, Wang J, Song X, Zheng W . Effect of AQP9 Expression in Androgen-Independent Prostate Cancer Cell PC3. Int J Mol Sci. 2016; 17(5). PMC: 4881560. DOI: 10.3390/ijms17050738. View

Imaizumi H, Ishibashi K, Takenoshita S, Ishida H . Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer. Oncol Lett. 2018; 15(5):6450-6456. PMC: 5920209. DOI: 10.3892/ol.2018.8170. View

Kusayama M, Wada K, Nagata M, Ishimoto S, Takahashi H, Yoneda M . Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. Cancer Sci. 2011; 102(6):1128-36. DOI: 10.1111/j.1349-7006.2011.01927.x. View

Huebert R, Jagavelu K, Hendrickson H, Vasdev M, Arab J, Splinter P . Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs. Am J Pathol. 2011; 179(4):1851-60. PMC: 3181328. DOI: 10.1016/j.ajpath.2011.06.045. View

Dorward H, Du A, Bruhn M, Wrin J, Pei J, Evdokiou A . Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro. J Exp Clin Cancer Res. 2016; 35:36. PMC: 4765103. DOI: 10.1186/s13046-016-0310-6. View

Bui L, Tomkiewicz C, Pierre S, Chevallier A, Barouki R, Coumoul X . Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration. Toxicol Sci. 2015; 149(1):158-66. DOI: 10.1093/toxsci/kfv221. View

Huo Z, Lomora M, Kym U, Palivan C, Holland-Cunz S, Gros S . AQP1 Is Up-Regulated by Hypoxia and Leads to Increased Cell Water Permeability, Motility, and Migration in Neuroblastoma. Front Cell Dev Biol. 2021; 9:605272. PMC: 7905035. DOI: 10.3389/fcell.2021.605272. View

Wang J, Gui Z, Deng L, Sun M, Guo R, Zhang W . c-Met upregulates aquaporin 3 expression in human gastric carcinoma cells via the ERK signalling pathway. Cancer Lett. 2012; 319(1):109-17. DOI: 10.1016/j.canlet.2011.12.040. View

Khan S, Ricciardelli C, Yool A . Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers. Cells. 2021; 10(2). PMC: 7911300. DOI: 10.3390/cells10020215. View

10.

Zhang Z, Han Y, Sun G, Liu X, Jia X, Yu X . MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma by down-regulation of aquaporin 5. Cell Mol Biol Lett. 2019; 24:13. PMC: 6373077. DOI: 10.1186/s11658-019-0137-1. View

11.

Li J, Wang Z, Chong T, Chen H, Li H, Li G . Over-expression of a poor prognostic marker in prostate cancer: AQP5 promotes cells growth and local invasion. World J Surg Oncol. 2014; 12:284. PMC: 4247740. DOI: 10.1186/1477-7819-12-284. View

12.

Cao C, Sun Y, Healey S, Bi Z, Hu G, Wan S . EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration. Biochem J. 2006; 400(2):225-34. PMC: 1652825. DOI: 10.1042/BJ20060816. View

13.

Russo A, Borrelli F . Bacopa monniera, a reputed nootropic plant: an overview. Phytomedicine. 2005; 12(4):305-17. DOI: 10.1016/j.phymed.2003.12.008. View

14.

Canales J, Morales D, Blanco C, Rivas J, Diaz N, Angelopoulos I . A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer. Front Physiol. 2019; 10:757. PMC: 6591513. DOI: 10.3389/fphys.2019.00757. View

15.

Hwang I, Jung S, Hwang E, Song S, Lee H, Kim S . Expression and localization of aquaporins in benign prostate hyperplasia and prostate cancer. Chonnam Med J. 2013; 48(3):174-8. PMC: 3539099. DOI: 10.4068/cmj.2012.48.3.174. View

16.

Xia H, Ma Y, Yu C, Li Y, Tang J, Li J . Aquaporin 3 knockdown suppresses tumour growth and angiogenesis in experimental non-small cell lung cancer. Exp Physiol. 2014; 99(7):974-84. DOI: 10.1113/expphysiol.2014.078527. View

17.

Chang H, Shi Y, Talaf T, Lin C . Aquaporin-8 mediates human esophageal cancer Eca-109 cell migration via the EGFR-Erk1/2 pathway. Int J Clin Exp Pathol. 2015; 7(11):7663-71. PMC: 4270600. View

18.

Fischer H, Stenling R, Rubio C, Lindblom A . Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors. BMC Physiol. 2001; 1:1. PMC: 32180. DOI: 10.1186/1472-6793-1-1. View

19.

Liu J, He X, Zou Y, Wang K . Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis. Dig Dis Sci. 2021; 67(6):2269-2282. DOI: 10.1007/s10620-021-07054-7. View

20.

Kitchen P, Day R, Taylor L, Salman M, Bill R, Conner M . Identification and Molecular Mechanisms of the Rapid Tonicity-induced Relocalization of the Aquaporin 4 Channel. J Biol Chem. 2015; 290(27):16873-81. PMC: 4505433. DOI: 10.1074/jbc.M115.646034. View