Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis

Overview

Journal Nutrients

Date 2023 Jan 21

PMID 36678310

Authors

Malgorzata Kaczkan

Sylwia Czaja-Stolc

Malgorzata Szczuko

Arleta Drozd

Przemyslaw Rutkowski

Alicja Debska-Slizien

Sylwia Malgorzewicz

Affiliations

Soon will be listed here.

Abstract

The concentration of water-soluble vitamins (except folic acid and vitamin B12) is not routinely measured, which may lead to undiagnosed deficiencies among hemodialysis (HD) patients. The aim of the study was to assess the blood concentration of water-soluble vitamins in HD patients in comparison with healthy subjects and to assess the impact of diabetes mellitus (DM) coexistence on the concentration of these vitamins. The two-center study included 142 HD patients and a control group of 31 healthy subjects. Vitamins concentration was determined using high-performance liquid chromatography (HPLC). Vitamin B1, B6, and B12 levels were significantly lower in the HD group than in the control group (p < 0.001). Vitamin B1 and B2 were negatively correlated with blood urea nitrogen (BUN) levels before HD (R = −0.39, R = −0.38; p < 0.05). Vitamin B3, B12, and C were positively correlated with the albumin concentration (R = 0.26, R = 0.27, R = 0.28; p < 0.05). Among diabetic patients, only the concentration of vitamin B1 was lower than among non-diabetic patients. The concentration of water-soluble vitamins may be related to the adequacy of dialysis, the time of laboratory determination since the last dialysis, diet, coexistence of other diseases, use of drugs, and dietary supplements in individual patients.

Citing Articles

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References

Mazzeo A, Barutta F, Bellucci L, Trento M, Gruden G, Porta M . Reduced Thiamine Availability and Hyperglycemia Impair Thiamine Transport in Renal Glomerular Cells through Modulation of Thiamine Transporter 2. Biomedicines. 2021; 9(4). PMC: 8067431. DOI: 10.3390/biomedicines9040385. View

Coveney N, Polkinghorne K, Linehan L, Corradini A, Kerr P . Water-soluble vitamin levels in extended hours hemodialysis. Hemodial Int. 2010; 15(1):30-8. DOI: 10.1111/j.1542-4758.2010.00505.x. View

Lenglet A, Liabeuf S, Guffroy P, Fournier A, Brazier M, Massy Z . Use of nicotinamide to treat hyperphosphatemia in dialysis patients. Drugs R D. 2013; 13(3):165-73. PMC: 3784056. DOI: 10.1007/s40268-013-0024-6. View

Pacal L, Kuricova K, Kankova K . Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?. World J Diabetes. 2014; 5(3):288-95. PMC: 4058733. DOI: 10.4239/wjd.v5.i3.288. View

Bossola M, Di Stasio E, Viola A, Leo A, Carlomagno G, Monteburini T . Dietary intake of trace elements, minerals, and vitamins of patients on chronic hemodialysis. Int Urol Nephrol. 2014; 46(4):809-15. DOI: 10.1007/s11255-014-0689-y. View

Deshmukh S, Prabhakar B, Kulkarni Y . Water Soluble Vitamins and their Role in Diabetes and its Complications. Curr Diabetes Rev. 2019; 16(7):649-656. DOI: 10.2174/1573399815666190916114040. View

Xiong R, Yuan Y, Zhu Z, Wu Y, Ha J, Han X . Micronutrients and Diabetic Retinopathy: Evidence From The National Health and Nutrition Examination Survey and a Meta-analysis. Am J Ophthalmol. 2022; 238:141-156. DOI: 10.1016/j.ajo.2022.01.005. View

Stein G, Sperschneider H, Koppe S . Vitamin levels in chronic renal failure and need for supplementation. Blood Purif. 1985; 3(1-3):52-62. DOI: 10.1159/000169398. View

Frank L . Thiamin in Clinical Practice. JPEN J Parenter Enteral Nutr. 2015; 39(5):503-20. DOI: 10.1177/0148607114565245. View

10.

Fissell R, Bragg-Gresham J, Gillespie B, Goodkin D, Bommer J, Saito A . International variation in vitamin prescription and association with mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis. 2004; 44(2):293-9. DOI: 10.1053/j.ajkd.2004.04.047. View

11.

Daugirdas J . The post: pre-dialysis plasma urea nitrogen ratio to estimate K.t/V and NPCR: mathematical modeling. Int J Artif Organs. 1989; 12(7):411-9. View

12.

Descombes E, Hanck A, Fellay G . Water soluble vitamins in chronic hemodialysis patients and need for supplementation. Kidney Int. 1993; 43(6):1319-28. DOI: 10.1038/ki.1993.185. View

13.

Jankowska M, Rudnicki-Velasquez P, Storoniak H, Rutkowski P, Rutkowski B, Krzyminski K . Thiamine Diphosphate Status and Dialysis-Related Losses in End-Stage Kidney Disease Patients Treated with Hemodialysis. Blood Purif. 2017; 44(4):294-300. DOI: 10.1159/000480651. View

14.

Nakatani-Enomoto S, Moriya A, Kikuchi S, Mochizuki H, Sugiura Y, Ugawa Y . [Wernicke encephalopathy in a non-alcoholic patient with diabetic nephropathy under hemodialysis]. Rinsho Shinkeigaku. 2010; 50(6):409-11. DOI: 10.5692/clinicalneurol.50.409. View

15.

Hong S, Yang D, Chang S . Plasma homocysteine, vitamin B6, vitamin B12 and folic acid in end-stage renal disease during low-dose supplementation with folic acid. Am J Nephrol. 1998; 18(5):367-72. DOI: 10.1159/000013378. View

16.

Ueda K, Takada D, Mii A, Tsuzuku Y, Saito S, Kaneko T . Severe thiamine deficiency resulted in Wernicke's encephalopathy in a chronic dialysis patient. Clin Exp Nephrol. 2006; 10(4):290-3. DOI: 10.1007/s10157-006-0440-9. View

17.

Lyon P, Strippoli V, Fang B, Cimmino L . B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease. Nutrients. 2020; 12(9). PMC: 7551072. DOI: 10.3390/nu12092867. View

18.

Lasseur C, Parrot F, Delmas Y, Level C, Ged C, Redonnet-Vernhet I . Impact of high-flux/high-efficiency dialysis on folate and homocysteine metabolism. J Nephrol. 2001; 14(1):32-5. View

19.

Schwotzer N, Kanemitsu M, Kissling S, Darioli R, Benghezal M, Rezzi S . Water-Soluble Vitamin Levels and Supplementation in Chronic Online Hemodiafiltration Patients. Kidney Int Rep. 2020; 5(12):2160-2167. PMC: 7710883. DOI: 10.1016/j.ekir.2020.09.009. View

20.

Angelini A, Cappuccilli M, Magnoni G, Chiocchini A, Aiello V, Napoletano A . The link between homocysteine, folic acid and vitamin B12 in chronic kidney disease. G Ital Nefrol. 2021; 38(4). View