Brain Nuclear Receptors and Cardiovascular Function

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2023 Jan 20

PMID 36670468

Authors

Mengjie Wang

Yongjie Yang

Yong Xu

Affiliations

Soon will be listed here.

Abstract

Brain-heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence indicates that a number of these brain NRs regulate multiple aspects of cardiovascular diseases (CVDs), including hypertension, heart failure, atherosclerosis, etc. In this review, we will elaborate recent findings that have established the physiological relevance of brain NRs in the context of cardiovascular function. In addition, we will discuss the currently available evidence regarding the distinct neuronal populations that respond to brain NRs in the cardiovascular control. These findings suggest connections between cardiac control and brain dynamics through NR signaling, which may lead to novel tools for the treatment of pathological changes in the CVDs.

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References

Kim E, Yoo Y, Yang W, Lim Y, Na T, Lee I . Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling. Arterioscler Thromb Vasc Biol. 2008; 28(10):1796-802. DOI: 10.1161/ATVBAHA.108.171546. View

Mittag J, Lyons D, Sallstrom J, Vujovic M, Dudazy-Gralla S, Warner A . Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions. J Clin Invest. 2012; 123(1):509-16. PMC: 3533300. DOI: 10.1172/JCI65252. View

Iorga A, Cunningham C, Moazeni S, Ruffenach G, Umar S, Eghbali M . The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biol Sex Differ. 2017; 8(1):33. PMC: 5655818. DOI: 10.1186/s13293-017-0152-8. View

Walsh B, Kuller L, Wild R, Paul S, Farmer M, Lawrence J . Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women. JAMA. 1998; 279(18):1445-51. DOI: 10.1001/jama.279.18.1445. View

Saleh T, Connell B . 17beta-estradiol modulates baroreflex sensitivity and autonomic tone of female rats. J Auton Nerv Syst. 2000; 80(3):148-61. DOI: 10.1016/s0165-1838(00)00087-4. View

Allenby G, Bocquel M, Saunders M, Kazmer S, Speck J, Rosenberger M . Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993; 90(1):30-4. PMC: 45593. DOI: 10.1073/pnas.90.1.30. View

Davey R, Grossmann M . Androgen Receptor Structure, Function and Biology: From Bench to Bedside. Clin Biochem Rev. 2016; 37(1):3-15. PMC: 4810760. View

Klein I, Danzi S . Thyroid disease and the heart. Circulation. 2007; 116(15):1725-35. DOI: 10.1161/CIRCULATIONAHA.106.678326. View

Razvi S . Novel uses of thyroid hormones in cardiovascular conditions. Endocrine. 2019; 66(1):115-123. PMC: 6794474. DOI: 10.1007/s12020-019-02050-4. View

10.

Koneru B, Bathina C, Cherry B, Mifflin S . Mineralocorticoid receptor in the NTS stimulates saline intake during fourth ventricular infusions of aldosterone. Am J Physiol Regul Integr Comp Physiol. 2013; 306(1):R61-6. PMC: 4073946. DOI: 10.1152/ajpregu.00434.2013. View

11.

Ghaddab-Zroud R, Seugnet I, Steffensen K, Demeneix B, Clerget-Froidevaux M . Liver X receptor regulation of thyrotropin-releasing hormone transcription in mouse hypothalamus is dependent on thyroid status. PLoS One. 2014; 9(9):e106983. PMC: 4167690. DOI: 10.1371/journal.pone.0106983. View

12.

Hamilton B, Frankel W, Kerrebrock A, HAWKINS T, Fitzhugh W, Kusumi K . Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996; 379(6567):736-9. DOI: 10.1038/379736a0. View

13.

Buonafine M, Bonnard B, Jaisser F . Mineralocorticoid Receptor and Cardiovascular Disease. Am J Hypertens. 2018; 31(11):1165-1174. DOI: 10.1093/ajh/hpy120. View

14.

LEHMAN J, Barger P, Kovacs A, Saffitz J, Medeiros D, Kelly D . Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest. 2000; 106(7):847-56. PMC: 517815. DOI: 10.1172/JCI10268. View

15.

Lin F, Qin J, Tang K, Tsai S, Tsai M . Coup d'Etat: an orphan takes control. Endocr Rev. 2011; 32(3):404-21. PMC: 3365794. DOI: 10.1210/er.2010-0021. View

16.

Wood H . Retinoid X receptor mediates brain clean-up after stroke. Nat Rev Neurol. 2020; 16(3):128-129. DOI: 10.1038/s41582-020-0315-9. View

17.

Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U . The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002; 110(2):251-60. DOI: 10.1016/s0092-8674(02)00825-5. View

18.

Heard D, Norby P, Holloway J, Vissing H . Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult. Mol Endocrinol. 2000; 14(3):382-92. DOI: 10.1210/mend.14.3.0431. View

19.

Reinchisi G, Ijichi K, Glidden N, Jakovcevski I, Zecevic N . COUP-TFII expressing interneurons in human fetal forebrain. Cereb Cortex. 2011; 22(12):2820-30. PMC: 3491767. DOI: 10.1093/cercor/bhr359. View

20.

Miranda D, Krause W, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo J . LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity. JCI Insight. 2018; 3(5). PMC: 5922282. DOI: 10.1172/jci.insight.96151. View