Coup D'Etat: an Orphan Takes Control

Overview

Journal Endocr Rev

Publisher Oxford University Press

Specialty Endocrinology

Date 2011 Jan 25

PMID 21257780

Citations 93

Authors

Fu-Jung Lin

Jun Qin

Ke Tang

Sophia Y Tsai

Ming-Jer Tsai

Affiliations

Soon will be listed here.

Abstract

Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) belong to the steroid/thyroid hormone receptor superfamily. Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because ligands for COUP-TFs have yet to be identified. Since 1998, extensive studies have demonstrated their physiological importance in cell-fate specification, organogenesis, angiogenesis, and metabolism, as well as a variety of diseases. In this article, we will comprehensively review the biological functions of COUP-TFII and its underlying mechanism in various developmental processes and diseases. In addition, we will briefly summarize some of the current findings of COUP-TFI.

Citing Articles

A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish.

Coppola U, Saha B, Kenney J, Waxman J PLoS Genet. 2024; 20(11):e1011222.

PMID: 39495809 PMC: 11563408. DOI: 10.1371/journal.pgen.1011222.

NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation.

Das S, Varshney R, Farriester J, Kyere-Davies G, Martinez A, Hill K bioRxiv. 2024; .

PMID: 39314382 PMC: 11419096. DOI: 10.1101/2024.09.09.611047.

Evidence for NR2F2/COUP-TFII involvement in human testis development.

Wankanit S, Zidoune H, Bignon-Topalovic J, Schlick L, Houzelstein D, Fusee L Sci Rep. 2024; 14(1):17869.

PMID: 39090159 PMC: 11294483. DOI: 10.1038/s41598-024-68860-3.

Zebrafish Congenital Heart Disease Models: Opportunities and Challenges.

Yang D, Jian Z, Tang C, Chen Z, Zhou Z, Zheng L Int J Mol Sci. 2024; 25(11).

PMID: 38892128 PMC: 11172925. DOI: 10.3390/ijms25115943.

Testicular differentiation in 46,XX DSD: an overview of genetic causes.

Ferrari M, Silva E, Nishi M, Batista R, Mendonca B, Domenice S Front Endocrinol (Lausanne). 2024; 15():1385901.

PMID: 38721146 PMC: 11076692. DOI: 10.3389/fendo.2024.1385901.

References

Lavine K, Long F, Choi K, Smith C, Ornitz D . Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development. Development. 2008; 135(18):3161-71. PMC: 4306353. DOI: 10.1242/dev.019919. View

Harrison M, Adzick N, ESTES J, Howell L . A prospective study of the outcome for fetuses with diaphragmatic hernia. JAMA. 1994; 271(5):382-4. View

Takamoto N, Kurihara I, Lee K, DeMayo F, Tsai M, Tsai S . Haploinsufficiency of chicken ovalbumin upstream promoter transcription factor II in female reproduction. Mol Endocrinol. 2005; 19(9):2299-308. PMC: 1198323. DOI: 10.1210/me.2005-0019. View

Fu M, Sun T, L Bookout A, Downes M, Yu R, Evans R . A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol Endocrinol. 2005; 19(10):2437-50. DOI: 10.1210/me.2004-0539. View

Riggs K, Wickramasinghe N, Cochrum R, Watts M, Klinge C . Decreased chicken ovalbumin upstream promoter transcription factor II expression in tamoxifen-resistant breast cancer cells. Cancer Res. 2006; 66(20):10188-98. DOI: 10.1158/0008-5472.CAN-05-3937. View

Wang V, Zoghbi H . Genetic regulation of cerebellar development. Nat Rev Neurosci. 2001; 2(7):484-91. DOI: 10.1038/35081558. View

Zhou C, Tsai S, Tsai M . COUP-TFI: an intrinsic factor for early regionalization of the neocortex. Genes Dev. 2001; 15(16):2054-9. PMC: 312763. DOI: 10.1101/gad.913601. View

Zhang P, Bennoun M, Gogard C, Bossard P, Leclerc I, Kahn A . Expression of COUP-TFII in metabolic tissues during development. Mech Dev. 2002; 119(1):109-14. DOI: 10.1016/s0925-4773(02)00286-1. View

Bergers G, Javaherian K, Lo K, Folkman J, Hanahan D . Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science. 1999; 284(5415):808-12. DOI: 10.1126/science.284.5415.808. View

10.

Wigle J, Oliver G . Prox1 function is required for the development of the murine lymphatic system. Cell. 1999; 98(6):769-78. DOI: 10.1016/s0092-8674(00)81511-1. View

11.

Armentano M, Filosa A, Andolfi G, Studer M . COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth. Development. 2006; 133(21):4151-62. DOI: 10.1242/dev.02600. View

12.

Ladias J, Karathanasis S . Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science. 1991; 251(4993):561-5. DOI: 10.1126/science.1899293. View

13.

Faedo A, Tomassy G, Ruan Y, Teichmann H, Krauss S, Pleasure S . COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex. 2008; 18(9):2117-31. PMC: 2733307. DOI: 10.1093/cercor/bhm238. View

14.

Lobov I, Renard R, Papadopoulos N, Gale N, Thurston G, Yancopoulos G . Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A. 2007; 104(9):3219-24. PMC: 1805530. DOI: 10.1073/pnas.0611206104. View

15.

Qin J, Suh J, Kim B, Yu C, Tanaka T, Kodama T . The expression pattern of nuclear receptors during cerebellar development. Dev Dyn. 2007; 236(3):810-20. DOI: 10.1002/dvdy.21060. View

16.

Adam F, Sourisseau T, Metivier R, Le Page Y, Desbois C, Michel D . COUP-TFI (chicken ovalbumin upstream promoter-transcription factor I) regulates cell migration and axogenesis in differentiating P19 embryonal carcinoma cells. Mol Endocrinol. 2000; 14(12):1918-33. DOI: 10.1210/mend.14.12.0562. View

17.

Lee D, Kurihara I, Jeong J, Lydon J, DeMayo F, Tsai M . Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization. Mol Endocrinol. 2010; 24(5):930-40. PMC: 2870934. DOI: 10.1210/me.2009-0531. View

18.

Tang K, Xie X, Park J, Jamrich M, Tsai S, Tsai M . COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010; 137(5):725-34. PMC: 2827684. DOI: 10.1242/dev.040568. View

19.

Francois M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C . Sox18 induces development of the lymphatic vasculature in mice. Nature. 2008; 456(7222):643-7. DOI: 10.1038/nature07391. View

20.

Qiu Y, Krishnan V, Zeng Z, Gilbert D, Copeland N, Gibson L . Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. Genomics. 1995; 29(1):240-6. DOI: 10.1006/geno.1995.1237. View