Estrogen Signaling Via Estrogen Receptor Alpha and Its Implications for Neurodegeneration Associated with Alzheimer's Disease in Aging Women

Overview

Journal Metab Brain Dis

Publisher Springer

Specialties Endocrinology
Neurology

Date 2023 Jan 14

PMID 36640216

Authors

Angeles C Tecalco-Cruz

Lilia Lopez-Canovas

Elisa Azuara-Liceaga

Affiliations

Soon will be listed here.

Abstract

Estrogen receptor alpha (ERα) is a transcription factor activated by estrogenic hormones to regulate gene expression in certain organs, including the brain. In the brain, estrogen signaling pathways are central for maintaining cognitive functions. Herein, we review the neuroprotective effects of estrogens mediated by ERα. The estrogen/ERα pathways are affected by the reduction of estrogens in menopause, and this event may be a risk factor for neurodegeneration associated with Alzheimer's disease in women. Thus, developing a better understanding of estrogen/ERα signaling may be critical for defining new biomarkers and potential therapeutic targets for Alzheimer's disease in women.

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