Metabolic Messengers: Glucagon

Overview

Journal Nat Metab

Publisher Springer Nature

Specialty Endocrinology

Date 2023 Jan 13

PMID 36639733

Authors

Patrick E MacDonald

Patrik Rorsman

Affiliations

Soon will be listed here.

Abstract

Plasma glucose is tightly regulated via the secretion of the two glucose-regulating hormones insulin and glucagon. Situated next to the insulin-secreting β-cells, the α-cells produce and secrete glucagon-one of the body's few blood glucose-increasing hormones. Diabetes is a bihormonal disorder, resulting from both inadequate insulin secretion and dysregulation of glucagon. The year 2023 marks the 100th anniversary of the discovery of glucagon, making it particularly timely to highlight the roles of this systemic metabolic messenger in health and disease.

Citing Articles

Blockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice.

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Increased dietary protein stimulates amino acid catabolism via the gut microbiota and secondary bile acid production.

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Lessons from a model: early glucagon dysfunction in type 2 diabetes.

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TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion.

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