Plasma GAS6 Predicts Mortality Risk in Acute Heart Failure Patients: Insights from the DRAGON-HF Trial

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2023 Jan 12

PMID 36635690

Authors

Teng Ma

Rongrong Huang

Yanhua Xu

Yangbo Lv

Yifan Liu

Xin Pan

Jia Dong

Di Gao

Zeyu Wang

Fenglei Zhang

Chunxi Yan

Sang-Bing Ong

Yang Su

Dachun Xu

Affiliations

Soon will be listed here.

Abstract

Background: Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein related to inflammation, fibrosis, as well as platelet function. Genetic ablation of GAS6 in mice protects against cardiac hypertrophy and dysfunction. Nonetheless, the association between plasma GAS6 levels and acute heart failure (AHF) patients is still unknown.

Methods: We measured plasma GAS6 concentrations in 1039 patients with AHF who were enrolled in the DRAGON-HF trial (NCT03727828). Mean follow-up of the study was 889 days. The primary endpoint is all-cause death.

Results: In total, there were 195 primary endpoints of all-cause death and 135 secondary endpoints of cardiovascular death during the mean follow-up duration of 889 days. The higher levels of GAS6 were associated with higher rates of all-cause and cardiovascular death (P < 0.05). Baseline plasma GAS6 levels were still strongly correlated with clinical outcomes in different models after adjustment for clinical factors and N-terminal pro-brain natriuretic peptide (NT-proBNP, P < 0.05). GAS6 could further distinguish the risks of clinical outcomes based on NT-proBNP measurement.

Conclusion: Elevated plasma GAS6 levels were associated with an increased risk of all-cause and cardiovascular death in patients with AHF. Trial registration NCT03727828 (DRAGON-HF trial) clinicaltrials.gov.

Citing Articles

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PMID: 39057085 PMC: 11275301. DOI: 10.3390/cimb46070444.

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