Analysis of Wearable Time Series Data in Endocrine and Metabolic Research

Overview

Journal Curr Opin Endocr Metab Res

Specialty Endocrinology

Date 2023 Jan 12

PMID 36632470

Authors

Azure D Grant

Thomas J Upton

John R Terry

Benjamin L Smarr

Eder Zavala

Affiliations

Soon will be listed here.

Abstract

Many hormones in the body oscillate with different frequencies and amplitudes, creating a dynamic environment that is essential to maintain health. In humans, disruptions to these rhythms are strongly associated with increased morbidity and mortality. While mathematical models can help us understand rhythm misalignment, translating this insight into personalised healthcare technologies requires solving additional challenges. Here, we discuss how combining minimally invasive, high-frequency biosampling technologies with wearable devices can assist the development of hormonal surrogates. We review bespoke algorithms that can help analyse multidimensional, noisy, time series data and identify wearable signals that could constitute clinical proxies of endocrine rhythms. These techniques can support the development of computational biomarkers to support the diagnosis and management of endocrine and metabolic conditions.

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