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The Effect of a Lipid Suspension on Amitriptyline Disposition

Overview
Journal Arch Toxicol
Specialty Toxicology
Date 1987 Aug 1
PMID 3662823
Citations 7
Authors
N A Minton
A G Goode
J A Henry
Affiliations
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Abstract

A 5-h infusion of a lipid suspension or saline was given on separate occasions to four healthy volunteers taking amitriptyline. Mean plasma levels of amitriptyline plus nortriptyline were 14% higher at the end of the lipid infusion but the difference was not statistically significant. Infusion of a lipid suspension is unlikely to materially affect the severity of amitriptyline intoxication.

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