Should We Consider the Infusion of Lipid Emulsion in the Resuscitation of Poisoned Patients?

Overview

Journal Crit Care

Specialty Critical Care

Date 2015 Feb 13

PMID 25673255

Citations 11

Authors

Grant Cave

Martyn G Harvey

Affiliations

Soon will be listed here.

Abstract

The use of intravenous lipid emulsions (ILEs) as antidote in local anaesthetic systemic toxicity has gained widespread support following convincing data from animal models, and successful case reports in humans. Proposed beneficial mechanisms of action for ILEs include intravascular sequestration of intoxicant and subsequent enhanced redistribution to biologically inert tissues, augmentation of fatty acid utilisation for ATP synthesis in the context of metabolic poisoning, and direct cardiotonic and ion channel effects. The evidence base for use of ILEs in acute drug intoxication is evolving. The present evidence supports use of ILEs only in local anaesthetic systemic toxicity and in lipophilic cardiotoxin intoxication when there is an immediate threat to life, and other therapies have proven ineffective.

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