Intraoral Lipoma with Degenerative Changes Mimicking Atypical Lipomatous Tumor: an Immunohistochemical Study

Overview

Journal Autops Case Rep

Date 2023 Jan 9

PMID 36619259

Authors

Evanio Vilela Silva

Heitor Albergoni Silveira

Beatriz Zamboni Martins Panucci

Kelly Fernanda Molena

Luciana Yamamoto Almeida

Andreia Bufalino

Jorge Esquiche Leon

Affiliations

Soon will be listed here.

Abstract

Lipomas are mesenchymal neoplasms relatively uncommon in the oral cavity. Lipomas can exhibit histopathological features mimicking atypical lipomatous tumors (ALT) or dysplastic lipoma (DL) in the presence of degenerative changes. Relevantly, immunohistochemistry assists in the correct diagnosis. Herein, we present the case of a 54-year-old male with a sessile nodule located on the dorsum of the tongue. The histopathological analysis showed a diffuse, non-circumscribed adipocytic proliferation constituted by cells of variable size containing cytoplasmic vacuoles and displaced nuclei, some resembling lipoblasts supported by fibrous connective tissue stroma. By immunohistochemistry, tumor cells were positive for vimentin, S100, FASN, CD10, and p16. Rb expression was intact. Moreover, CD34, p53, MDM2, and CDK4 were negative. After 2-year of follow-up, no alteration or recurrence was observed. In conclusion, MDM2, CDK4, p53, and Rb immunomarkers can be used reliably to differentiate benign lipoma with degenerative changes from ALT and DL.

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